Anti-TBR2/Eomes Antibody Picoband® Fluoro647 Conjugated

Eomesodermin also known as T-box brain protein 2 (Tbr2) is a protein that in humans is encoded by the EOMES gene. This gene belongs to the TBR1 (T-box brain protein 1) sub-family of T-box genes that share the common DNA-binding T-box domain. The encoded protein is a transcription factor which is crucial for embryonic development of mesoderm and the central nervous system in vertebrates. The protein may also be necessary for the differentiation of effector CD8+ T cells which are involved in defense against viral infections. A similar gene disrupted in mice is shown to be essential during trophoblast development and gastrulation. Alternative splicing results in multiple transcript variants.

Cell Type Marker,2339, Developmental Biology, Epigenetics and Nuclear Signaling, Germ Cell Markers, Germline Stem Cells, Intracellular, Lineage Specification, Neural Signal Transduction, Neural Stem Cells, Neurogenesis, Neurology Process, Neuron Marker, Neuroscience, Reproduction, Stem Cells

Functions as a transcriptional activator playing a crucial role during development. Functions in trophoblast differentiation and later in gastrulation, regulating both mesoderm delamination and endoderm specification. Plays a role in brain development being required for the specification and the proliferation of the intermediate progenitor cells and their progeny in the cerebral cortex. Also involved in the differentiation of CD8+ T-cells during immune response regulating the expression of lytic effector genes.

1. Arnold SJ, Huang GJ, Cheung AF, Era T, Nishikawa S, Bikoff EK, Molnár Z, Robertson EJ, Groszer M (2008) . The T-box transcription factor Eomes/Tbr2 regulates neurogenesis in the cortical subventricular zone. Genes & Development. 22 (18) : 2479–84. 2. Sessa A, Mao CA, Hadjantonakis AK, Klein WH, Broccoli V (Oct 2008) . Tbr2 s conversion of radial glia into basal precursors and guides neuronal amplification by in neurogenesis in the developing neocortex glish. Neuron. 60 (1) : 56–69.