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Anti-CLPP Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

ATP-dependent Clp protease proteolytic subunit (ClpP) is an enzyme that in humans is encoded by the CLPP gene. It is mapped to 19p13.3. The protein encoded by this gene belongs to the peptidase family S14 and hydrolyzes proteins into small peptides in the presence of ATP and magnesium. The protein is transported into mitochondrial matrix and is associated with the inner mitochondrial membrane.

Synonyms

ATP-dependent Clp protease proteolytic subunit, mitochondrial; Endopeptidase Clp; CLPP

Gene Name

CLPP

Gene ID

8192

UniProt

Q16740

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E. coli-derived human CLPP recombinant protein (Position: A184-H247) .

Clonality

Polyclonal

Tissue Specificity

Detected in liver (at protein level) . Predominantly expressed in skeletal muscle. Intermediate levels in heart, liver and pancreas. Low in brain, placenta, lung and kidney.

Applications

Flow Cytometry

Field of Research

Cancer, Metabolism, Mitochondrial, Mitochondrial Markers, Mitochondrial Metabolism, Pathways and Processes, Signal Transduction

Purification

Immunogen affinity purified.

Form

Liquid

Function

Protease component of the Clp complex that cleaves peptides and various proteins in an ATP-dependent process. Has low peptidase activity in the absence of CLPX. The Clp complex can degrade CSN1S1, CSN2 and CSN3, as well as synthetic peptides (in vitro) and may be responsible for a fairly general and central housekeeping function rather than for the degradation of specific substrates.

References & Citations

1. Entrez Gene: CLPP ClpP caseinolytic peptidase, ATP-dependent, proteolytic subunit homolog (E. coli) . 2. Bross P, Andresen BS, Knudsen I, Kruse TA, Gregersen N (Feb 1996) . Human ClpP protease: cDNA sequence, tissue-specific expression and chromosomal assignment of the gene. FEBS Lett. 377 (2) : 249–52. 3. Corydon, TJ; Bross, P; Holst, HU; Neve, S; Kristiansen, K; Gregersen, N; Bolund, L (1 April 1998) . A human homologue of Escherichia coli ClpP caseinolytic protease: recombinant expression, intracellular processing and subcellular localization.. The Biochemical Journal. 331 (1) : 309–16.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Caseinolytic mitochondrial matrix peptidase proteolytic subunit

Subcellular Location

Mitochondrion matrix.

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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