Anti-Creatine kinase B type/CKB Antibody Picoband® Fluoro488 Conjugated

Brain-type creatine kinase also known as CK-BB is a creatine kinase that in humans is encoded by the CKB gene. The protein encoded by this gene is a cytoplasmic enzyme involved in energy homeostasis. The encoded protein reversibly catalyzes the transfer of phosphate between ATP and various phosphogens such as creatine phosphate. It acts as a homodimer in brain as well as in other tissues, and as a heterodimer with a similar muscle isozyme in heart. The encoded protein is a member of the ATP:guanido phosphotransferase protein family. A pseudogene of this gene has been characterized.

Cancer, Cell Biology, Oncoproteins, Oncoproteins/Suppressors, Proteasome / Ubiquitin, Proteolysis/Ubiquitin, Ring Finger E3 Ligase, Tumor Antigens, Tumor Biomarkers, Tumor Immunology, Tumor-Associated Antigens, Ubiquitin E3 Enzymes

Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate) . Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.

1. Mariman EC, Schepens JT, Wieringa B (August 1989) . Complete nucleotide sequence of the human creatine kinase B gene. Nucleic Acids Res. 17 (15) : 6385. 2. Benger, J. C., Teshima, I., Walter, M. A., Brubacher, M. G., Daouk, G. H., Cox, D. W. Localization and genetic linkage of the human immunoglobulin heavy chain genes and the creatine kinase brain (CKB) gene: identification of a hot spot for recombination. Genomics 9: 614-622, 1991.