Anti-CEP68 Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
Centrosomal protein of 68 kDa is a protein that in humans is encoded by the CEP68 gene. It is mapped to chromosome 2. CEP68 is required for centrosome cohesion. It decorates fibres emanating from the proximal ends of centrioles. CEP68 and rootletin depend both on each other for centriole association, and both also require CEP250 for their function.
Synonyms
Centrosomal protein of 68 kDa; Cep68; CEP68; KIAA0582
Gene Name
CEP68
Gene ID
23177
UniProt
Q76N32
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human CEP68, which shares 73.2% and 75.6% amino acid (aa) sequence identity with mouse and rat EP68, respectively.
Clonality
Polyclonal
Tissue Specificity
Present in many fetal and adult tissues. Mainly expressed in adult skeletal muscle, thymus, testis, ovary, and pancreas, low or absent in brain and peripheral blood leukocytes.
Applications
Flow Cytometry
Field of Research
Organelles, Subcellular Markers, Tags & Cell Markers
Purification
Immunogen affinity purified.
Form
Liquid
Function
Involved in maintenance of centrosome cohesion, probably as part of a linker structure which prevents centrosome splitting (PubMed:18042621) . Required for localization of CDK5RAP2 to the centrosome during interphase (PubMed:24554434, PubMed:25503564) .
References & Citations
1. Fang, G., Zhang, D., Yin, H., Zheng, L., Bi, X., Yuan, L. Centlein mediates an interaction between C-Nap1 and Cep68 to maintain centrosome cohesion. J. Cell Sci. 127: 1631-1639, 2014. 2. Graser, S., Stierhof, Y.-D., Nigg, E. A. Cep68 and Cep215 (Cdk5rap2) are required for centrosome cohesion. J. Cell. Sci. 120: 4321-4331, 2007. 3. Man, X., Megraw, T. L., Lim, Y. P. Cep68 can be regulated by Nek2 and SCF complex. Europ. J. Cell Biol. 94: 162-172, 2015.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Centrosomal protein 68
Subcellular Location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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