Anti-BTG2 Antibody Picoband® Fluoro647 Conjugated
Product Specifications
Background
Protein BTG2, also known as BTG family member 2 or NGF-inducible anti-proliferative protein PC3 or NGF-inducible protein TIS21, is a protein that in humans is encoded by the BTG2 gene. The protein encoded by the gene BTG2 is a member of the BTG/Tob family. This protein controls cell cycle progression and proneural genes expression by acting as a transcription coregulator that enhances or inhibits the activity of transcription factors.
Synonyms
Protein BTG2; BTG family member 2; NGF-inducible anti-proliferative protein PC3; BTG2; PC3
Gene Name
BTG2
Gene ID
7832
UniProt
P78543
Host
Rabbit
Reactivity
Human
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of human BTG2, which shares 88.9% amino acid (aa) sequence identity with both mouse and rat BTG2.
Clonality
Polyclonal
Tissue Specificity
Widely expressed. Detected in adult colon epithelium.
Applications
Flow Cytometry
Field of Research
Epigenetics and Nuclear Signaling, Neurogenesis, Neurology Process, Neuroscience, Transcription
Purification
Immunogen affinity purified.
Form
Liquid
Function
Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex. Activates mRNA deadenylation in a CNOT6 and CNOT7-dependent manner. In vitro can inhibit deadenylase activity of CNOT7 and CNOT8. Involved in cell cycle regulation. Could be involved in the growth arrest and differentiation of the neuronal precursors (By similarity) . Modulates transcription regulation mediated by ESR1. Involved in mitochondrial depolarization and neurite outgrowth.
References & Citations
1. Entrez Gene: BTG2 BTG family, member 2. 2. Rouault JP, Falette N, Guéhenneux F, Guillot C, Rimokh R, Wang Q, Berthet C, Moyret-Lalle C, Savatier P, Pain B, Shaw P, Berger R, Samarut J, Magaud JP, Ozturk M, Samarut C, Puisieux A (December 1996) . Identification of BTG2, an antiproliferative p53-dependent component of the DNA damage cellular response pathway. Nature Genetics. 14 (4) : 482–6.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
43363 MW
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
BTG anti-proliferation factor 2
Subcellular Location
Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Cell membrane; Distributed throughout the cytosol when the kinase is not activated. Association with microtubules requires activation of the kinase activity. Shuttles between focal adhesions and cell-cell contacts in epithelial cells. Recruited to the lateral cell membrane in polarized epithelial cells by interaction with phosphorylated EZR. Detected at tubular membrane structures in the cytoplasm and at the cell periphery.
Protein Name
Keratin, type I cytoskeletal 14
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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