Anti-Prosurfactant Protein B/SFTPB Antibody Picoband® Fluoro647 Conjugated

Pulmonary surfactant-associated protein B is a protein that in humans is encoded by the SFTPB gene. This gene encodes the pulmonary-associated surfactant protein B (SPB), an amphipathic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a surface-active lipoprotein complex composed of 90% lipids and 10% proteins which include plasma proteins and apolipoproteins SPA, SPB, SPC and SPD. The surfactant is secreted by the alveolar cells of the lung and maintains the stability of pulmonary tissue by reducing the surface tension of fluids that coat the lung. The SPB enhances the rate of spreading and increases the stability of surfactant monolayers in vitro. Multiple mutations in this gene have been identified, which cause pulmonary surfactant metabolism dysfunction type 1, also called pulmonary alveolar proteinosis due to surfactant protein B deficiency, and are associated with fatal respiratory distress in the neonatal period. Alternatively spliced transcript variants encoding the same protein have been identified.

Pulmonary surfactant-associated protein B; SP-B; 18 kDa pulmonary-surfactant protein; 6 kDa protein; Pulmonary surfactant-associated proteolipid SPL (Phe) ; SFTPB; SFTP3

A synthetic peptide corresponding to a sequence at the C-terminus of human SFTPB, which shares 80% amino acid (aa) sequence identity with both mouse and rat SFTPB.

Cancer, Cardiovascular, Cell Biology, Cell Cycle, Cell Differentiation, Lipases, Lipid and Lipoprotein Metabolism, Lipid Metabolism, Lipids/Lipoproteins, Metabolic Signaling Pathways, Metabolism, Pathways and Processes, Signal Transduction, Vasculature

Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air- liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter.

1. Tredano, M., Cooper, D. N., Stuhrmann, M., Christodoulou, J., Chuzhanova, N. A., Roudot-Thoraval, F., Boelle, P.-Y., Elion, J., Jeanpierre, M., Feingold, J., Couderc, R., Bahuau, M. Origin of the prevalent SFTPB Indel g.1549C-GAA (121ins2) mutation causing surfactant protein B (SP-B) deficiency. Am. J. Med. Genet. 140A: 62-69, 2006. 2. Tredano, M., van Elburg, R. M., Kaspers, A. G., Zimmermann, L. J., Houdayer, C., Aymard, P., Hull, W. M., Whitsett, J. A., Elion, J., Griese, M., Bahuau, M. Compound SFTPB 1549C-to-GAA (121ins2) and 457delC heterozygosity in severe congenital lung disease and surfactant protein B (SP-B) deficiency. Hum. Mutat. 14: 502-509, 1999.