Anti-PLAU Antibody Picoband® Fluoro488 Conjugated

Urokinase, also known as urokinase-type plasminogen activator (uPA), is a serine protease present in humans and other animals. This gene encodes a secreted serine protease that converts plasminogen to plasmin. The encoded preproprotein is proteolytically processed to generate A and B polypeptide chains. These chains associate via a single disulfide bond to form the catalytically inactive high molecular weight urokinase-type plasminogen activator (HMW-uPA) . HMW-uPA can be further processed into the catalytically active low molecular weight urokinase-type plasminogen activator (LMW-uPA) . This low molecular weight form does not bind to the urokinase-type plasminogen activator receptor. Mutations in this gene may be associated with Quebec platelet disorder and late-onset Alzheimer's disease. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.

Urokinase-type plasminogen activator; U-plasminogen activator; uPA; Urokinase-type plasminogen activator long chain A; Urokinase-type plasminogen activator short chain A; Urokinase-type plasminogen activator chain B; PLAU

1. Degryse, Bernard (1 June 2011) . The urokinase receptor system as strategic therapeutic target: challenges for the 21st century. Current Pharmaceutical Design. 17 (19) : 1872–1873. 2. Tang, Linlin; Han, Xiuzhen (March 2013) . The urokinase plasminogen activator system in breast cancer invasion and metastasis. Biomedicine & Pharmacotherapy. 67 (2) : 179–182.