Anti-Neuropeptide S/NPS Antibody Fluoro647 Conjugated

Neuropeptide S (NPS) is a neuropeptide found in human and mammalian brain, mainly produced by neurons in the amygdala and between Barrington's nucleus and the locus coeruleus, although NPS-responsive neurons extend projections into many other brain areas. NPS binds specifically to a G protein-coupled receptor, NPSR. Animal studies show that NPS suppresses anxiety and appetite, induces wakefulness and hyperactivity, including hyper-sexuality, and plays a significant role in the extinction of conditioned fear.It has also been shown to significantly enhance dopamine activity in the mesolimbic pathway, and inhibits motility and increases permeability in neurocrine fashion acting through NO in the myenteric plexus in rats and humans.

A synthetic peptide corresponding to a sequence at the C-terminus of human Neuropeptide S, which shares 80% amino acid (aa) sequence identity with both mouse and rat Neuropeptide S.

Modulates arousal and anxiety. May play an important anorexigenic role (By similarity) . Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations (PubMed:15312648, PubMed:16790440) .

1. Meis S, Bergado-Acosta JR, Yanagawa Y, Obata K, Stork O, Munsch T (2008) . Grothe B, ed. Identification of a neuropeptide S responsive circuitry shaping amygdala activity via the endopiriform nucleus. PloS One. 3 (7) : e2695. 2. Reinscheid RK, Xu YL (Dec 2005) . Neuropeptide S and its receptor: a newly deorphanized G protein-coupled receptor system. The Neuroscientist. 11 (6) : 532–8.