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Anti-MAP2 Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

Microtubule-associated protein 2 is a protein that in humans is encoded by the MAP2 gene. This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The products of similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dentrites, implicating a role in determining and stabilizing dentritic shape during neuron development. A number of alternatively spliced variants encoding distinct isoforms have been described.

Synonyms

Microtubule-associated protein 2; MAP-2; MAP2

Gene Name

MAP2

Gene ID

4133

UniProt

P11137

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E. coli-derived human MAP2 recombinant protein (Position: Q64-L133) .

Clonality

Polyclonal

Applications

Flow Cytometry

Field of Research

Cell Type Marker, Cytoskeleton, Cytoskeleton/ECM, Microtubules, Neural Stem Cells, Neuron Marker, Neuroscience, Signal Transduction, Stem Cells

Purification

Immunogen affinity purified.

Form

Liquid

Function

The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.

References & Citations

1. Kalcheva N, Albala J, O'Guin K, Rubino H, Garner C, Shafit-Zagardo B (December 1995) . Genomic structure of human microtubule-associated protein 2 (MAP-2) and characterization of additional MAP-2 isoforms.Proc Natl Acad Sci U S A. 92 (24) : 10894–8. 2. Neve RL, Harris P, Kosik KS, Kurnit DM, Donlon TA (May 1987) . Identification of cDNA clones for the human microtubule-associated protein tau and chromosomal localization of the genes for tau and microtubule-associated protein 2. Brain Res. 387 (3) : 271–80.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Microtubule-associated protein 2

Subcellular Location

Cytoplasm, cytoskeleton. Cell projection, dendrite.

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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