Anti-P2RY5/LPAR6 Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
Lysophosphatidic acid receptor 6 also known as LPA6, P2RY5, and GPR87, is a protein that in humans is encoded by the LPAR6 gene. The protein encoded by this gene belongs to the family of G-protein coupled receptors, that are preferentially activated by adenosine and uridine nucleotides. This gene aligns with an internal intron of the retinoblastoma susceptibility gene in the reverse orientation. Alternative splicing results in multiple transcript variants.
Synonyms
Lysophosphatidic acid receptor 6; LPA receptor 6; LPA-6; Oleoyl-L-alpha-lysophosphatidic acid receptor; P2Y purinoceptor 5; P2Y5; Purinergic receptor 5; RB intron encoded G-protein coupled receptor; LPAR6; P2RY5
Gene Name
LPAR6
Gene ID
10161
UniProt
P43657
Host
Rabbit
Reactivity
Human
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human P2RY5, which shares 92.3% and 89.7% amino acid (aa) sequence identity with mouse and rat P2RY5, respectively.
Clonality
Polyclonal
Tissue Specificity
Expressed ubiquitously, including in skin and hair follicle cells. Detected in both Henle's and Huxley's layers of the inner root sheath of the hair follicle and in suprabasal layers of the epidermis (at protein level) . Expressed at low levels in peripheral blood leukocytes.
Applications
Flow Cytometry
Field of Research
G Protein Signaling, Signal Transduction, Signaling Pathway
Purification
Immunogen affinity purified.
Form
Liquid
Function
Binds to oleoyl-L-alpha-lysophosphatidic acid (LPA) . Intracellular cAMP is involved in the receptor activation. Important for the maintenance of hair growth and texture.
References & Citations
1. Nahum, S., Morice-Picard, F., Taieb, A., Sprecher, E. A novel mutation in LPAR6 causes autosomal recessive hypotrichosis of the scalp. Clin. Exp. Derm. 36: 188-194, 2010. 2. Shimomura, Y., Wajid, M., Ishii, Y., Shapiro, L., Petukhova, L., Gordon, D., Christiano, A. M.Disruption of P2RY5, an orphan G protein-coupled receptor, underlies autosomal recessive woolly hair. Nature Genet. 40: 335-339, 2008.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
101272 MW
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Lysophosphatidic acid receptor 6
Subcellular Location
Cell membrane.
Protein Name
N-alpha-acetyltransferase 15, NatA auxiliary subunit
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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