Anti-ICOS Antibody Fluoro647 Conjugated
Product Specifications
Background
Inducible T-cell costimulator is an immune checkpoint protein that in humans is encoded by the ICOS gene. The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation.
Synonyms
Inducible T-cell costimulator; Activation-inducible lymphocyte immunomediatory molecule; CD278; ICOS; AILIM
Gene Name
ICOS
Gene ID
29851
UniProt
Q9Y6W8
Host
Rabbit
Reactivity
Human
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E. coli-derived human ICOS recombinant protein (Position: E21-K140) .
Clonality
Polyclonal
Tissue Specificity
Activated T-cells. Highly expressed on tonsillar T-cells, which are closely associated with B-cells in the apical light zone of germinal centers, the site of terminal B- cell maturation. Expressed at lower levels in thymus, lung, lymph node and peripheral blood leukocytes. Expressed in the medulla of fetal and newborn thymus.
Applications
Flow Cytometry
Field of Research
Adaptive Immunity, Immunology, T Cells
Purification
Immunogen affinity purified.
Form
Liquid
Function
Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up- regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up- regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre- activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes (By similarity) .
References & Citations
1. Hutloff A, Dittrich AM, Beier KC, Eljaschewitsch B, Kraft R, Anagnostopoulos I, Kroczek RA (Jan 1999) . ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28. Nature. 397 (6716) : 263–6. 2. Rudd CE, Schneider H (Jul 2003) . Unifying concepts in CD28, ICOS and CTLA4 co-receptor signalling. Nature Reviews. Immunology. 3 (7) : 544–56.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Inducible T cell co-stimulator
Subcellular Location
Isoform 1: Cell membrane ; Single-pass type I membrane protein.
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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