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Anti-ICOS Antibody

Boster Bio Anti-ICOS Antibody Picoband® catalog # A00291-3. Tested in ELISA, Flow Cytometry, IHC, ICC applications. This antibody reacts with Human.

Product Specifications

Background

Inducible T-cell costimulator is an immune checkpoint protein that in humans is encoded by the ICOS gene. The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation.

Synonyms

Inducible T-cell costimulator; Activation-inducible lymphocyte immunomediatory molecule; CD278; ICOS; AILIM

Gene Name

ICOS

Gene ID

29851

UniProt

Q9Y6W8

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E. coli-derived human ICOS recombinant protein (Position: E21-K140) .

Clonality

Polyclonal

Tissue Specificity

Activated T-cells. Highly expressed on tonsillar T-cells, which are closely associated with B-cells in the apical light zone of germinal centers, the site of terminal B- cell maturation. Expressed at lower levels in thymus, lung, lymph node and peripheral blood leukocytes. Expressed in the medulla of fetal and newborn thymus.

Applications

ELISA, Flow Cytometry, IHC, ICC

Field of Research

Adaptive Immunity, Immunology, T Cells

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up- regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up- regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre- activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes (By similarity) .

References & Citations

1. Hutloff A, Dittrich AM, Beier KC, Eljaschewitsch B, Kraft R, Anagnostopoulos I, Kroczek RA (Jan 1999) . ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28. Nature. 397 (6716) : 263–6. 2. Rudd CE, Schneider H (Jul 2003) . Unifying concepts in CD28, ICOS and CTLA4 co-receptor signalling. Nature Reviews. Immunology. 3 (7) : 544–56.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

20 kDa

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Inducible T cell co-stimulator

Subcellular Location

Isoform 1: Cell membrane ; Single-pass type I membrane protein.

Isotype

Rabbit IgG

Contents

243

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