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Anti-Connexin 32/GJB1 Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

Gap junction beta-1 protein (GJB1), also known as connexin 32 (Cx32) is a transmembrane protein that in humans is encoded by the GJB1 gene. This gene encodes a member of the gap junction protein family. The gap junction proteins are membrane-spanning proteins that assemble to form gap junction channels that facilitate the transfer of ions and small molecules between cells. According to sequence similarities at the nucleotide and amino acid levels, the gap junction proteins are divided into two categories, alpha and beta. Mutations in this gene cause X-linked Charcot-Marie-Tooth disease, an inherited peripheral neuropathy. Alternatively spliced transcript variants encoding the same protein have been found for this gene.

Synonyms

Gap junction beta-1 protein; Connexin-32; Cx32; GAP junction 28 kDa liver protein; GJB1; CX32

Gene Name

GJB1

Gene ID

2705

UniProt

P08034

Host

Rabbit

Reactivity

Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

A synthetic peptide corresponding to a sequence in the middle region of human Connexin 32/GJB1, identical to the related mouse and rat sequences.

Clonality

Polyclonal

Applications

Flow Cytometry

Field of Research

Neuroscience, Neurotransmission, Receptors / Channels

Purification

Immunogen affinity purified.

Form

Liquid

Function

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

References & Citations

1. Corcos IA, Lafreniere RG, Begy CR, Loch-Caruso R, Willard HF, Glover TW (Jul 1992) . Refined localization of human connexin32 gene locus, GJB1, to Xq13.1. Genomics 13 (2) : 479–80. 2. Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008) . Novel MITF targets identified using a two-step DNA microarray strategy. Pigment Cell Melanoma Res. 21 (6) : 665–76.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Gap junction protein, beta 1, 32kDa

Subcellular Location

Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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