Anti-Galanin Antibody Picoband® Fluoro550 Conjugated

Galanin is a neuropeptide encoded by the GAL gene, that is widely expressed in the brain, spinal cord, and gut of humans as well as other mammals. This gene encodes a neuroendocrine peptide that is widely expressed in the central and peripheral nervous systems and also the gastrointestinal tract, pancreas, adrenal gland and urogenital tract. The encoded protein is a precursor that is proteolytically processed to generate two mature peptides: galanin and galanin message-associated peptide (GMAP) . Galanin has diverse physiological functions including nociception, feeding and energy homeostasis, osmotic regulation and water balance. GMAP has been demonstrated to possess antifungal activity and hypothesized to be part of the innate immune system.

A synthetic peptide corresponding to a sequence in the middle region of human Galanin, which shares 86.2% amino acid (aa) sequence identity with both mouse and rat Galanin.

Endocrine hormone of the central and peripheral nervous systems that binds and activates the G protein-coupled receptors GALR1, GALR2, and GALR3. This small neuropeptide may regulate diverse physiologic functions including contraction of smooth muscle of the gastrointestinal and genitourinary tract, growth hormone and insulin release and adrenal secretion.

1. Mitsukawa K, Lu X, Bartfai T (June 2008) . Galanin, galanin receptors and drug targets. Cell. Mol. Life Sci. 65 (12) : 1796–805. 2. Wu Z, Autry AE, Bergan JF, Watabe-Uchida M, Dulac CG (May 2014) .Galanin neurons in the medial preoptic area govern parental behaviour. Nature. 509 (7500) : 325–30.