Anti-E74 like factor 1/ELF1 Antibody Picoband® Fluoro647 Conjugated
Product Specifications
Background
E74-like factor 1 (ets domain transcription factor) is a protein that in humans is encoded by the ELF1 gene. It is mapped to chromosome 13q13. This gene encodes an E26 transformation-specific related transcription factor. The encoded protein is primarily expressed in lymphoid cells and acts as both an enhancer and a repressor to regulate transcription of various genes. Alternative splicing results in multiple transcript variants.
Synonyms
ETS-related transcription factor Elf-1; E74-like factor 1; ELF1
Gene Name
ELF1
Gene ID
1997
UniProt
P32519
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
A synthetic peptide corresponding to a sequence in the middle region of human E74 like factor 1, which shares 81.6% amino acid (aa) sequence identity with both mouse and rat E74 like factor 1.
Clonality
Polyclonal
Tissue Specificity
In fetal tissues, it is highly expressed in heart, lung liver and kidney, and weakly expressed in brain. In adult, it is highly expressed in pancreas, spleen, thymus and peripheral blood leukocytes, expressed at moderate levels in heart, placenta, lung, liver, skeletal muscle, kidney, prostate, ovary, small intestine and colon, and weakly expressed in brain and testis.
Applications
Flow Cytometry
Field of Research
Domain Families, Epigenetics and Nuclear Signaling, Transcription
Purification
Immunogen affinity purified.
Form
Liquid
Function
Transcription factor that activates the LYN and BLK promoters. Appears to be required for the T-cell-receptor-mediated trans activation of HIV-2 gene expression. Binds specifically to two purine-rich motifs in the HIV-2 enhancer.
References & Citations
1. Aryee, D. N. T., Petermann, R., Kos, K., Henn, T., Haas, O. A., Kovar, H. Cloning of a novel human ELF-1-related ETS transcription factor, ELFR, its characterization and chromosomal assignment relative to ELF-1. Gene 210: 71-78, 1998. 2. Hollenhorst, P. C., Shah, A. A., Hopkins, C., Graves, B. J. Genome-wide analyses reveal properties of redundant and specific promoter occupancy within the ETS gene family.Genes Dev. 21: 1882-1894, 2007.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
E74 like ETS transcription factor 1
Subcellular Location
Nucleus.
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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