Anti-TWEAK/TNFSF12 Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
Tumor necrosis factor ligand superfamily member 12 also known as TNF-related weak inducer of apoptosis (TWEAK) is a protein that in humans is encoded by the TNFSF12 gene. The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine, which exists in both membrane-bound and secreted forms, can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. Alternative splicing results in multiple transcript variants.
Synonyms
Tumor necrosis factor ligand superfamily member 12; APO3 ligand; TNF-related weak inducer of apoptosis; TWEAK; Tumor necrosis factor ligand superfamily member 12, membrane form; Tumor necrosis factor ligand superfamily member 12, secreted form; TNFSF12; APO3L, DR3LG; UNQ181/PRO207
Gene Name
TNFSF12
Gene ID
8742
UniProt
O43508
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E. coli-derived human TWEAK recombinant protein (Position: S94-H249) .
Clonality
Polyclonal
Tissue Specificity
Highly expressed in adult heart, pancreas, skeletal muscle, brain, colon, small intestine, lung, ovary, prostate, spleen, lymph node, appendix and peripheral blood lymphocytes. Low expression in kidney, testis, liver, placenta, thymus and bone marrow. Also detected in fetal kidney, liver, lung and brain.
Applications
Flow Cytometry
Field of Research
Apoptosis, Cancer, Cell Biology, Cell Death, Growth Factors, Invasion/Microenvironment
Purification
Immunogen affinity purified.
Form
Liquid
Function
Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines. Promotes IL8 secretion.
References & Citations
1. Entrez Gene: TNFSF12 tumor necrosis factor (ligand) superfamily, member 12. 2. Chicheportiche Y, Bourdon PR, Xu H, Hsu YM, Scott H, Hession C, Garcia I, Browning JL (December 1997) . TWEAK, a new secreted ligand in the tumor necrosis factor family that weakly induces apoptosis. The Journal of Biological Chemistry. 272 (51) : 32401–10.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
62616 MW
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
TNF superfamily member 12
Subcellular Location
Cell membrane.
Protein Name
Bifunctional epoxide hydrolase 2
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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