Anti-CD11c/ITGAX Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
CD11c, also known as Integrin, alpha X (complement component 3 receptor 4 subunit) (ITGAX), is a genethat encodes for CD11c. This gene encodes the integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4) . The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles. Two transcript variants encoding different isoforms have been found for this gene.
Synonyms
Integrin alpha-X; CD11 antigen-like family member C; Leu M5; Leukocyte adhesion glycoprotein p150,95 alpha chain; Leukocyte adhesion receptor p150,95; CD11c; ITGAX; CD11C
Gene Name
ITGAX
Gene ID
3687
UniProt
P20702
Host
Rabbit
Reactivity
Human, Mouse
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E. coli-derived human CD11c recombinant protein (Position: S161-T342) .
Clonality
Polyclonal
Tissue Specificity
Predominantly expressed in monocytes and granulocytes.
Applications
Flow Cytometry
Field of Research
Cell Adhesion, Cell Type Markers, Cytoskeleton/ECM, Hematopoietic Progenitors, Immunology, Integrins, Lymphoid, Myeloid, Signal Transduction, Stem Cells, T Lymphocytic Lineage
Purification
Immunogen affinity purified.
Form
Liquid
Function
Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis.
References & Citations
1. Entrez Gene: ITGAX integrin, alpha X (complement component 3 receptor 4 subunit) . 2. Córbi AL, Lopéz-Rodríguez C (1997) . CD11c integrin gene promoter activity during myeloid differentiation.. Leuk. Lymphoma. 25 (5-6) : 415–25.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
132494 MW
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Integrin subunit alpha X
Subcellular Location
Membrane; Single-pass type I membrane protein.
Protein Name
Leptin receptor
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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