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Anti-IL18 binding protein/Il18bp Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

Interleukin-18-binding protein is a protein that in humans is encoded by the IL18BP gene. The protein encoded by this gene functions as an inhibitor of the proinflammatory cytokine, IL18. It binds IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production, resulting in reduced T-helper type 1 immune responses. This protein is constitutively expressed and secreted in mononuclear cells. Elevated level of this protein is detected in the intestinal tissues of patients with Crohn's disease. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Synonyms

Interleukin-18-binding protein; IL-18BP; Interferon gamma-inducing factor-binding protein; Il18bp; Igifbp

Gene Name

Il18bp

Gene ID

16068

UniProt

Q9Z0M9

Host

Rabbit

Reactivity

Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E. coli-derived mouse IL18 binding protein recombinant protein (Position: T29-A193) .

Clonality

Polyclonal

Tissue Specificity

Ubiquitous.

Applications

Flow Cytometry

Field of Research

Interleukins

Purification

Immunogen affinity purified.

Form

Liquid

Function

Binds to IL-18 and inhibits its activity. Functions as an inhibitor of the early TH1 cytokine response (By similarity) . .

References & Citations

1. Entrez Gene: IL18BP interleukin 18 binding protein. 2. Novick D, Kim SH, Fantuzzi G, Reznikov LL, Dinarello CA, Rubinstein M (Mar 1999) . Interleukin-18 binding protein: a novel modulator of the Th1 cytokine response. Immunity. 10 (1) : 127–36.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

67166 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Interleukin 18 binding protein

Subcellular Location

Secreted.

Protein Name

Suppressor of tumorigenicity 7 protein

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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