Anti-ICAM2 Antibody Picoband® Fluoro647 Conjugated

Intercellular adhesion molecule 2 (ICAM2), also known as CD102 (Cluster of Differentiation 102), is a human gene. The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance. Several transcript variants encoding the same protein have been found for this gene.

Highly expressed in lung. Also detected in pancreas, kidney, small intestine, ovary, testis, prostate and mammary gland. In lung, it is found in alveolar type II cells but not in bronchiolar epithelium.

ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2) . ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen- specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance.

1. Entrez Gene: ICAM2 intercellular adhesion molecule 2. 2. Heiska L, Alfthan K, Grönholm M, Vilja P, Vaheri A, Carpén O (August 1998) . Association of ezrin with intercellular adhesion molecule-1 and -2 (ICAM-1 and ICAM-2) . Regulation by phosphatidylinositol 4, 5-bisphosphate. The Journal of Biological Chemistry. 273 (34) : 21893–900. 3. Xiao X, Mruk DD, Cheng CY (2013) . Intercellular adhesion molecules (ICAMs) and spermatogenesis.Human Reproduction Update. 19 (2) : 167–86.