What sizes are available for Anti-ICAM1 Antibody Picoband® Fluoro594 Conjugated?

Anti-ICAM1 Antibody Picoband® Fluoro594 Conjugated is available in the following size(s): 100 µg/Vial.

What is the isotype of this antibody?

Isotype information such as IgG1 or IgG2a is listed in the product specifications on the datasheet, relevant for selecting compatible detection reagents.

Can I get a trial-size or discounted first order of this product?

We don’t generally offer free samples, but trial discounts in exchange for feedback and validation results are almost always possible. Contact us with your intended application to arrange one.

Do you offer bulk or custom quantities of this product?

Yes. Ordering two or more units, or combining this with other products, usually qualifies for a discount depending on quantity. Contact our sales team with your required volume for a custom quote.

Anti-ICAM1 Antibody Picoband® Fluoro594 Conjugated

Q: What is the catalog number for Anti-ICAM1 Antibody Picoband® Fluoro594 Conjugated?

The catalog number for Anti-ICAM1 Antibody Picoband® Fluoro594 Conjugated is A00171-Fluoro594.

Q: Is Anti-ICAM1 Antibody Picoband® Fluoro594 Conjugated in stock?

Anti-ICAM1 Antibody Picoband® Fluoro594 Conjugated is currently made to order / not held in immediate stock. Contact us for lead time.

Selected Variant

A00171-Fluoro594

Size: 100 µg/Vial

Product Specifications

Background

CD54, also known as ICAM-1. Intercellular adhesion molecule-1 (ICAM1) is a ligand for lymphocyte function-associated (LFA) antigens. ICAM-1 is an integral membrane protein, a member of the immunoglobulin superfamily, and a ligand for LFA-1, a beta 2 leukocyte integrin. This protein is the major human rhinovirus receptor. The ICAM1 gene is mapped to human chromosome 19. In humans, lymphocyte adhesion to cells is mediated by the protein heterodimer CD11a/CD18 (Leu-CAMa, LFA-1) and its ligand CD54 (ICAM-1) .

Synonyms

Intercellular adhesion molecule 1; ICAM-1; Major group rhinovirus receptor; CD54; ICAM1

Gene Name

ICAM1

Gene ID

3383

UniProt

P05362

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E. coli-derived human ICAM1 recombinant protein (Position: Q28-R268) .

Clonality

Polyclonal

Tissue Specificity

Present in T-cells, monocytes, epithelial cells and hepatocytes (at protein level) . Ubiquitously expressed, with highest levels in heart, skeletal muscle, liver, placenta and peripheral blood leukocytes. .

Applications

Flow Cytometry

Field of Research

Adaptive Immunity, Atherosclerosis, Cardiovascular, Cell Adhesion Molecules, Cell Type Markers, Hematopoietic Progenitors, Immunology, Lymphoid, Stem Cells, T Lymphocytic Lineage, Vascular Inflammation

Purification

Immunogen affinity purified.

Form

Liquid

Function

ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2) . During leukocyte trans- endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation.

References & Citations

1. Ballantyne, C. M.; Kozak, C. A.; O'Brien, W. E.; Beaudet, A. L. : Assignment of the gene for intercellular adhesion molecule-1 (Icam-1) to proximal mouse chromosome 9. Genomics 9: 547-550, 1991. 2. Greve, J. M.; Davis, G.; Meyer, A. M.; Forte, C. P.; Yost, S. C.; Marlor, C. W.; Kamarck, M. E.; McClelland, A. : The major human rhinovirus receptor is ICAM-1. Cell 56: 839-847, 1989. 3. Prieto, J.; Takei, F.; Gendelman, R.; Christenson, B.; Biberfeld, P.; Patarroyo, M. : MALA-2, mouse homologue of human adhesion molecule ICAM-1 (CD54) . Europ. J. Immun. 19: 1551-1557, 1989.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

56528 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

Gene Name Synonym

Intercellular adhesion molecule 1

Subcellular Location

Membrane; Single-pass type I membrane protein.

Isotype

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

Price

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