Anti-Prothrombin/F2 Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
F2 (Coagulation Factor II), also known as thrombin, is a serine protease that in humans is encoded by the F2 gene. This gene for human prothrombin (F2) was assigned to chromosome 11p11-q12 by analysis of a panel of somatic cell hybrid DNAs and by in situ hybridization, using both cDNA and genomic probes. The activated thrombin enzyme plays an important role in hemostasis and thrombosis: it converts fibrinogen to fibrin for blood clot formation, stimulates platelet aggregation, and activates coagulation factors V, VIII (F8), and XIII (F13A1) . Thrombin also inhibits coagulation by activating protein C.
Synonyms
Prothrombin; Coagulation factor II; Activation peptide fragment 1; Activation peptide fragment 2; Thrombin light chain; Thrombin heavy chain; F2
Gene Name
F2
Gene ID
2147
UniProt
P00734
Host
Rabbit
Reactivity
Human
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E. coli-derived human Prothrombin recombinant protein (Position: Y67-R124) .
Clonality
Polyclonal
Tissue Specificity
Expressed by the liver and secreted in plasma.
Applications
Flow Cytometry
Field of Research
Calcium Signaling, Endocrine System, G Protein Signaling, More Gpcr, Neuroscience, Neurotransmission, Receptors / Channels, Signal Transduction, Signaling Pathway
Purification
Immunogen affinity purified.
Form
Liquid
Function
Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing.
References & Citations
1. Lancellotti, S., De Cristofaro, R. Congenital prothrombin deficiency. Semin. Thromb. Hemost. 35: 367-381, 2009. 2. Royle, N. J., Irwin, D. M., Koschinsky, M. L., MacGillivray, R. T. A., Hamerton, J. L. Human genes encoding prothrombin and ceruloplasmin map to 11p11-q12 and 3q21-24, respectively. Somat. Cell Molec. Genet. 13: 285-292, 1987.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Coagulation factor II (thrombin)
Subcellular Location
Secreted, extracellular space.
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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