Anti-TAPA1/CD81 Antibody Picoband®

CD81 molecule, also known as CD81 (Cluster of Differentiation 81), is a protein which in humans is encoded by the CD81 gene. The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This protein appears to promote muscle cell fusion and support myotube maintenance. Also it may be involved in signal transduction. This gene is localized in the tumor-suppressor gene region and thus it is a candidate gene for malignancies. Two transcript variants encoding different isoforms have been found for this gene.

May play an important role in the regulation of lymphoma cell growth. Interacts with a 16-kDa Leu-13 protein to form a complex possibly involved in signal transduction. May act as the viral receptor for HCV.

1. Andria ML, Hsieh CL, Oren R, Francke U, Levy S (August 1991) .Genomic organization and chromosomal localization of the TAPA-1 gene.Journal of Immunology. 147 (3) : 1030–6. 2. Levy S, Todd SC, Maecker HT (1998) . CD81 (TAPA-1) : a molecule involved in signal transduction and cell adhesion in the immune system..Annu Rev Immunol. 16: 89–109.

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.