Anti-TL1A/TNFSF15 Antibody Picoband® Fluoro594 Conjugated

Vascular endothelial growth inhibitor (VEGI), also known as TNF-like ligand 1A (TL1A) and TNF superfamily member 15 (TNFSF15), is protein that in humans is encoded by the TNFSF15 gene. The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Two transcript variants encoding different isoforms have been found for this gene.

Tumor necrosis factor ligand superfamily member 15; TNF ligand-related molecule 1; Vascular endothelial cell growth inhibitor; Tumor necrosis factor ligand superfamily member 15; membrane form; Tumor necrosis factor ligand superfamily member 15; secreted form; TNFSF15; TL1; VEGI

Specifically expressed in endothelial cells. Detected in monocytes, placenta, lung, liver, kidney, skeletal muscle, pancreas, spleen, prostate, small intestine and colon.

Receptor for TNFRSF25 and TNFRSF6B. Mediates activation of NF-kappa-B. Inhibits vascular endothelial growth and angiogenesis (in vitro) . Promotes activation of caspases and apoptosis.

1. Entrez Gene: TNFSF15 tumor necrosis factor (ligand) superfamily, member 15. 2. Picornell Y, Mei L, Taylor K, Yang H, Targan SR, Rotter JI (Nov 2007) . TNFSF15 is an ethnic-specific IBD gene. Inflammatory Bowel Diseases. 13 (11) : 1333–8.