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Anti-CD252/Tnfsf4 Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

OX40L (TNFSF4) is the ligand for CD134 and is expressed on such cells as DC2s (a subtype of dendritic cells) enabling amplification of Th2 cell differentiation. This gene encodes a cytokine of the tumor necrosis factor (TNF) ligand family. The encoded protein functions in T cell antigen-presenting cell (APC) interactions and mediates adhesion of activated T cells to endothelial cells. Polymorphisms in this gene have been associated with Sjogren's syndrome and systemic lupus erythematosus. Alternative splicing results in multiple transcript variants.

Synonyms

Tumor necrosis factor ligand superfamily member 4; OX40 ligand; OX40L; CD252; Tnfsf4; Ox40l; Txgp1l

Gene Name

Tnfsf4

Gene ID

22164

UniProt

P43488

Host

Rabbit

Reactivity

Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E. coli-derived mouse CD252 recombinant protein (Position: Q49-L198) . Mouse CD252 shares 42.7% and 78.8% amino acid (aa) sequence identity with human and rat CD252, respectively.

Clonality

Polyclonal

Tissue Specificity

Macrophages; peripheral blood leukocytes, lung, spleen and liver.

Applications

Flow Cytometry

Field of Research

Adaptive Immunity, Autoimmune, B Cells, Cell Type Markers, Cytokines, Immune System Diseases, Immunology, Innate Immunity, T Cells, TNF Superfamily

Purification

Immunogen affinity purified.

Form

Liquid

Function

Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production.

References & Citations

1. Graham, D. S. C., Graham, R. R., Manku, H., Wong, A. K., Whittaker, J. C., Gaffney, P. M., Moser, K. L., Rioux, J. D., Altshuler, D., Behrens, T. W., Vyse, T. J. Polymorphism at the TNF superfamily gene TNFSF4 confers susceptibility to systemic lupus erythematosus. Nature Genet. 40: 83-89, 2008. 2. Koch, W., Hoppmann, P., Mueller, J. C., Schomig, A., Kastrati, A. Lack of support for association between common variation in TNFSF4 and myocardial infarction in a German population. (Letter) Nature Genet. 40: 1386-1387, 2008.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Tumor necrosis factor (ligand) superfamily, member 4

Subcellular Location

Membrane; Single-pass type II membrane protein.

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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