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Anti-Tal1 Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

T-cell acute lymphocytic leukemia protein 1 is a protein that in humans is encoded by the TAL1 gene. The protein encoded by TAL1 is a basic helix-loop-helix transcription factor. TAL1 is a transcriptionally complex gene that is expressed throughout development, activating or repressing transcription in hematopoietic, neural, and endothelial precursors. This gene is mapped to chromosome 1p33.

Synonyms

T-cell acute lymphocytic leukemia protein 1; TAL-1; Class A basic helix-loop-helix protein 17; bHLHa17; Stem cell protein; T-cell leukemia/lymphoma protein 5; TAL1; BHLHA17; SCL; TCL5

Gene Name

TAL1

Gene ID

6886

UniProt

P17542

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E. coli-derived human Tal1 recombinant protein (Position: Y174-D259) .

Clonality

Polyclonal

Tissue Specificity

Leukemic stem cell.

Applications

Flow Cytometry

Field of Research

Cell Differentiation, Developmental Biology, Epigenetics and Nuclear Signaling, Hematopoietic Progenitors, Organogenesis, Stem Cells

Purification

Immunogen affinity purified.

Form

Liquid

Function

Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation (By similarity) .

References & Citations

1. Hosur, V., Cox, M. L., Burzenski, L. M., Riding, R. L., Alley, L., Lyons, B. L., Kavirayani, A., Martin, K. A., Cox, G. A., Johnson, K. R., Shultz, L. D. Retrotransposon insertion in the T-cell acute lymphocytic leukemia 1 (Tal1) gene is associated with severe renal disease and patchy alopecia in hairpatches (Hpt) mice. PLoS One 8: e53426, 2013. Note: Electronic Article. 2. Hu, X., Li, X., Valverde, K., Fu, X., Noguchi, C., Qiu, Y., Huang, S. LSD1-mediated epigenetic modification is required for TAL1 function and hematopoiesis. Proc. Nat. Acad. Sci. 106: 10141-10146, 2009.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

50408 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

TAL bHLH transcription factor 1, erythroid differentiation factor

Subcellular Location

Nucleus.

Protein Name

Protein C-ets-1

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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