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Anti-RNF186 Antibody Picoband® Fluoro647 Conjugated

Selected Variant

A15259-1-Fluoro647

Size: 100 µg/Vial

Product Specifications

Background

RNF186 is an E3 ubiquitin ligase that regulates endoplasmic reticulum (ER) stress and apoptosis through its interaction with BNIP1. This gene is mapped to chromosome 1p36.13 based on an alignment of theRNF186 sequence with the genomic sequence (GRCh38) . Cotransfection and immunoprecipitation analyses showed that RNF186, through it transmembrane domains, interacted with BNIP1. Overexpression of RNF186 promoted BNIP1 ubiquitination and transfer of BNIP1 to mitochondria.

Synonyms

RING finger protein 186; RNF186

Gene Name

RNF186

Gene ID

54546

UniProt

Q9NXI6

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E. coli-derived human RNF186 recombinant protein (Position: R86-L159) .

Clonality

Polyclonal

Tissue Specificity

Detected in liver, skeletal muscle, kidney, pancreas, spleen, thyroid, testis, ovary, small intestine and colon.

Applications

Flow Cytometry

Field of Research

Cell Biology

Purification

Immunogen affinity purified.

Form

Liquid

Function

Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance.

References & Citations

1. Gross, M. B. Personal Communication. Baltimore, Md. 10/18/2016. 2. Wang, P., Wu, Y., Li, Y., Zheng, J., Tang, J. A novel RING finger E3 ligase RNF186 regulates ER stress-mediated apoptosis through interaction with BNip1. Cell. Signal. 25: 2320-2333, 2013.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

24145 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

RING finger protein 186

Subcellular Location

Membrane ; Multi-pass membrane protein .

Protein Name

Transmembrane protein 240

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

Price

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