Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Anti-RECK Antibody Picoband®

Boster Bio Anti-RECK Antibody Picoband® catalog # A06439-1. Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Product Specifications

Background

Reversion-inducing-cysteine-rich protein with kazal motifs, also known as RECK, is a human gene, thought to be a metastasis suppressor. The protein encoded by this gene is a cysteine-rich, extracellular protein with protease inhibitor-like domains whose expression is suppressed strongly in many tumors and cells transformed by various kinds of oncogenes. In normal cells, this membrane-anchored glycoprotein may serve as a negative regulator for matrix metalloproteinase-9, a key enzyme involved in tumor invasion and metastasis. Several transcript variants encoding different isoforms have been found for this gene.

Synonyms

Reversion-inducing cysteine-rich protein with Kazal motifs; hRECK; Suppressor of tumorigenicity 15 protein; RECK; ST15

Gene Name

RECK

Gene ID

8434

UniProt

O95980

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

A synthetic peptide corresponding to a sequence in the middle region of human RECK, which shares 88.6% and 79.5% amino acid (aa) sequence identity with mouse and rat RECK, respectively.

Clonality

Polyclonal

Tissue Specificity

Expressed in various tissues and untransformed cells. It is undetectable in tumor-derived cell lines and oncogenically transformed cells.

Applications

WB

Field of Research

Cancer, Cell Biology, Oncoproteins/Suppressors, Protease Inhibitors, Proteolysis/Ubiquitin, Tumor Suppressors

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Negatively regulates matrix metalloproteinase-9 (MMP-9) by suppressing MMP-9 secretion and by inhibition of its enzymatic activity. RECK down-regulation by oncogenic signals may facilitate tumor invasion and metastasis. Appears to also regulate MMP-2 and MT1-MMP, which are involved in cancer progression.

References & Citations

1. Entrez Gene: RECK reversion-inducing-cysteine-rich protein with kazal motifs. 2. Park, S., Lee, C., Sabharwal, P., Zhang, M., Meyers, C. L. F., Sockanathan, S. GDE2 promotes neurogenesis by glycosylphosphatidylinositol-anchor cleavage of RECK. Science 339: 324-328, 2013.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

110 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Reversion inducing cysteine rich protein with kazal motifs

Subcellular Location

Cell membrane; Lipid-anchor, GPI-anchor.

Isotype

Rabbit IgG

Contents

243

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

ELP2 Human Pre-designed siRNA Set A
HY-RS04329 1 Set

ELP2 Human Pre-designed siRNA Set A

Ask
View Details
Rabbit anti-Schizosaccharomyces pombe (strain 972/24843)(Fission yeast) SPCC569.01c Polyclonal Antibody
MBS9015509 Inquire

Rabbit anti-Schizosaccharomyces pombe (strain 972/24843)(Fission yeast) SPCC569.01c Polyclonal Antibody

Ask
View Details
KRT83 (Keratin, Type II Cuticular Hb3, Type II Hair Keratin Hb3, Keratin-83, K83, Hair Keratin K2.10, KRTHB3, MGC141663) (MaxLight 550)
128969-ML550 100 µL

KRT83 (Keratin, Type II Cuticular Hb3, Type II Hair Keratin Hb3, Keratin-83, K83, Hair Keratin K2.10, KRTHB3, MGC141663) (MaxLight 550)

Ask
View Details
Bovine Ornithine Decarboxylase ODC ELISA Kit
BG-BVN11709 1 Each

Bovine Ornithine Decarboxylase ODC ELISA Kit

Ask
View Details
Mouse CASP10 (Caspase 10) CLIA Kit
MBS2530786-01 96 Tests

Mouse CASP10 (Caspase 10) CLIA Kit

Ask
View Details
Mouse CASP10 (Caspase 10) CLIA Kit
MBS2530786-02 5x 96 Tests

Mouse CASP10 (Caspase 10) CLIA Kit

Ask
View Details