Anti-PTPN22 Antibody Picoband®

Protein tyrosine phosphatase, non-receptor type 22 (lymphoid), also known as PTPN22, is a protein that in humans is encoded by the PTPN22 gene. This gene encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. The encoded protein is a lymphoid-specific intracellular phosphatase that associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Mutations in this gene may be associated with a range of autoimmune disorders including Type 1 Diabetes, rheumatoid arthritis, systemic lupus erythematosus and Graves' disease. Alternatively spliced transcript variants encoding distinct isoforms have been described.

Tyrosine-protein phosphatase non-receptor type 22; Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP; PEST-domain phosphatase; PEP; Ptpn22; Ptpn8

Acts as negative regulator of T-cell receptor (TCR) signaling by dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules (By similarity) . Associates with and probably dephosphorylates CBL (By similarity) . Dephosphorylates LCK at its activating 'Tyr-394' residue (By similarity) . Dephosphorylates ZAP70 at its activating 'Tyr-492' residue (By similarity) . Dephosphorylates the immune system activator SKAP2 (By similarity) . Positively regulates toll-like receptor (TLR) -induced type 1 interferon production (PubMed:23871208) . Promotes host antiviral responses mediated by type 1 interferon (PubMed:23871208) . Regulates NOD2-induced pro- inflammatory cytokine secretion and autophagy (PubMed:23991106) .

1. Cohen S, Dadi H, Shaoul E, Sharfe N, Roifman CM (March 1999) . Cloning and characterization of a lymphoid-specific, inducible human protein tyrosine phosphatase, Lyp. Blood 93 (6) : 2013–24. 2. Cloutier JF, Veillette A (September 1996) .Association of inhibitory tyrosine protein kinase p50csk with protein tyrosine phosphatase PEP in T cells and other hemopoietic cells. EMBO J. 15 (18) : 4909–18. 3. Matthews RJ, Bowne DB, Flores E, Thomas ML (May 1992) . Characterization of hematopoietic intracellular protein tyrosine phosphatases: description of a phosphatase containing an SH2 domain and another enriched in proline-, glutamic acid-, serine-, and threonine-rich sequences.Mol. Cell. Biol. 12 (5) : 2396–405.

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.