Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Anti-IL23/IL23A Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

Interleukin-23 subunit alpha is a protein that in humans is encoded by the IL23A gene. IL-23, also known as Interleukin-23 subunit alphainin (IL23A), is a heterodimeric cytokine consisting of two subunits, one called p40, which is shared with another cytokine, IL-12, and another called p19 (the IL-23 alpha subunit) . The International Radiation Hybrid Mapping Consortium mapped the IL-23 gene to chromosome 12. IL-23 is an important part of the inflammatory response against infection. It promotes upregulation of the matrix metalloprotease MMP9, increases angiogenesis and reduces CD8+ T-cell infiltration.

Synonyms

Interleukin-23 subunit alpha; IL-23 subunit alpha; IL-23-A; Interleukin-23 subunit p19; IL-23p19; IL23A; SGRF; UNQ2498/PRO5798

Gene Name

IL23A

Gene ID

51561

UniProt

Q9NPF7

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E. coli-derived human IL23 recombinant protein (Position: R20-R178) .

Clonality

Polyclonal

Tissue Specificity

Secreted by activated dendritic and phagocytic cells and keratinocytes. Also expressed by dermal Langerhans cells (at protein level) .

Applications

Flow Cytometry

Field of Research

Cytokines, Immunology, Innate Immunity

Purification

Immunogen affinity purified.

Form

Liquid

Function

Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak- Stat signaling cascade, stimulates memory rather than naive T- cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.

References & Citations

1. Hu, W., Dehmel, T., Pirhonen, J., Hartung, H.-P., Kieseier, B. C.Interleukin 23 in acute inflammatory demyelination of the peripheral nerve.Arch. Neurol. 63: 858-864, 2006. 2. Kullberg, M. C., Jankovic, D., Feng, C. G., Hue, S., Gorelick, P. L., McKenzie, B. S., Cua, D. J., Powrie, F., Cheever, A. W., Maloy, K. J., Sher, A.IL-23 plays a key role in Helicobacter hepaticus-induced T cell-dependent colitis.J. Exp. Med. 203: 2485-2494, 2006. 3. Oppmann, B., Lesley, R., Blom, B., Timans, J. C., Xu, Y., Hunte, B., Vega, F., Yu, N., Wang, J., Singh, K., Zonin, F., Vaisberg, E., and 13 others.Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12.Immunity 13: 715-725, 2000.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Interleukin 23 subunit alpha

Subcellular Location

Secreted.

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

More Discoveries

Explore Other Products

Browse additional items from our catalog

Anti-ADGRE1 antibody (DMC481) ; IgG1 Chimeric mAb
12-9457-100 100 µg

Anti-ADGRE1 antibody (DMC481) ; IgG1 Chimeric mAb

Sign In for Pricing
View Details
Recombinant Human 3-ketoacyl-CoA thiolase, His, Yeast-100ug
QP5603-ye-100ug 100ug

Recombinant Human 3-ketoacyl-CoA thiolase, His, Yeast-100ug

Sign In for Pricing
View Details
CASC3 Polyclonal Antibody, AbBy Fluor™ 750 Conjugated
bs-4097R-BF750 100 µL

CASC3 Polyclonal Antibody, AbBy Fluor™ 750 Conjugated

Sign In for Pricing
View Details
Rat TMPRSS11D shRNA Plasmid
abx986305-01 150 µg

Rat TMPRSS11D shRNA Plasmid

Sign In for Pricing
View Details
Rat TMPRSS11D shRNA Plasmid
abx986305-02 300 µg

Rat TMPRSS11D shRNA Plasmid

Sign In for Pricing
View Details
Fluor Violet 450 Anti-Mouse TCRbeta Antibody [H57-597 (HB218)]
MBS2570380-01 50 Tests

Fluor Violet 450 Anti-Mouse TCRbeta Antibody [H57-597 (HB218)]

Sign In for Pricing
View Details