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Anti-IL17/Il17a Antibody Picoband® Fluoro647 Conjugated

Selected Variant

A00421-2-Fluoro647

Size: 100 µg/Vial

Product Specifications

Background

Interleukin-17A is a protein that in humans is encoded by the IL17A gene. The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO) . High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.

Synonyms

Interleukin-17A; IL-17; IL-17A; Cytotoxic T-lymphocyte-associated antigen 8; CTLA-8; Il17a; Ctla8; Il17

Gene Name

Il17a

Gene ID

16171

UniProt

Q62386

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E. coli-derived mouse IL17 recombinant protein (Position: A26-A158) .

Clonality

Polyclonal

Tissue Specificity

Restricted to a subset of activated T-cells.

Applications

Flow Cytometry

Field of Research

Cytokines, Immunology, Innate Immunity, Interleukins, Macrophage/Inflammation

Purification

Immunogen affinity purified.

Form

Liquid

Function

Ligand for IL17RA (PubMed:17911633) . The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC (By similarity) . Involved in inducing stromal cells to produce proinflammatory and hematopoietic cytokines (By similarity) .

References & Citations

1. Entrez Gene: IL17A interleukin 17A. 2. Rouvier E, Luciani MF, Mattéi MG, Denizot F, Golstein P (June 1993) . CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a herpesvirus saimiri gene. Journal of Immunology. 150 (12) : 5445–56.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Interleukin 17A

Subcellular Location

Secreted.

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

Price

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