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Anti-IL1F10 Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

Interleukin-1 family member 10 is a protein that in humans is encoded by the IL1F10 gene. The protein encoded by this gene is a member of the interleukin 1 cytokine family. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. This cytokine is thought to participate in a network of interleukin 1 family members to regulate adapted and innate immune responses.

Synonyms

Interleukin 1 family member 10 ; Interleukin 1 family, member 10 (Predicted) ; Il1f10 ; Il1f10_predicted ; rCG_45898

Gene Name

Il1f10

Gene ID

362077

UniProt

D4A9I5

Host

Rabbit

Reactivity

Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E. coli-derived rat IL1F10 recombinant protein (Position: M1-R152) .

Clonality

Polyclonal

Tissue Specificity

Expressed in fetal skin, spleen and tonsil. Expressed mostly in the basal epithelia of skin and in proliferating B-cells of the tonsil.

Applications

Flow Cytometry

Field of Research

Cytokines, Immunology, Innate Immunity, Interleukins

Purification

Immunogen affinity purified.

Form

Liquid

Function

Cytokine with immunomodulatory activity. Alone, does not induce cytokine production, but reduces IL22 and IL17A production by T-cells in response to heat-killed Candida albicans. Reduces IL36G-induced production of IL8 by peripheral blood mononuclear cells. Increases IL6 production by dendritic cells stimulated by bacterial lipopolysaccharides (LPS) . Ligand for IL-36R/IL1RL2.

References & Citations

1. Bensen JT, Dawson PA, Mychaleckyj JC, Bowden DW (Dec 2001) . Identification of a novel human cytokine gene in the interleukin gene cluster on chromosome 2q12-14. J Interferon Cytokine Res. 21 (11) : 899–904. 2. Taylor SL, Renshaw BR, Garka KE, Smith DE, Sims JE (May 2002) . Genomic organization of the interleukin-1 locus. Genomics. 79 (5) : 726–33.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

17081 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Interleukin 1 family member 10 (theta)

Subcellular Location

Secreted .

Protein Name

Nck-associated protein 1

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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