Anti-ETV6/Tel Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

Transcription factor ETV6 is a protein that in humans is encoded by the ETV6 gene. This gene encodes an ETS family transcription factor. The product of this gene contains two functional domains: a N-terminal pointed (PNT) domain that is involved in protein-protein interactions with itself and other proteins, and a C-terminal DNA-binding domain. Gene knockout studies in mice suggest that it is required for hematopoiesis and maintenance of the developing vascular network. This gene is known to be involved in a large number of chromosomal rearrangements associated with leukemia and congenital fibrosarcoma.

Synonyms

Transcription factor ETV6; ETS translocation variant 6; ETS-related protein Tel1; Tel; ETV6; TEL; TEL1

Gene Name

ETV6

Gene ID

2120

UniProt

P41212

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E. coli-derived human ETV6/Tel recombinant protein (Position: E327-Q448) .

Clonality

Polyclonal

Tissue Specificity

Ubiquitous.

Applications

Flow Cytometry

Field of Research

Cancer Susceptibility, Domain Families, Epigenetics and Nuclear Signaling, Proto-Oncogenes, Transcription, Transcription Factors

Purification

Immunogen affinity purified.

Form

Liquid

Function

Transcriptional repressor; binds to the DNA sequence 5'- CCGGAAGT-3'. Plays a role in hematopoiesis and malignant transformation.

References & Citations

1. Entrez Gene: ETV6 ets variant gene 6 (TEL oncogene) . 2. Chiosea SI, Griffith C, Assaad A, Seethala RR (Sep 2012) . Clinicopathological characterization of mammary analogue secretory carcinoma of salivary glands. Histopathology. 61 (3) : 387–94.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Specificity

No cross reactivity with other proteins.

Applications Notes

Gene Name Synonym

ETS variant 6

Subcellular Location

Nucleus.

Isotype

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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Anti-ETV6/Tel Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

Synonyms

Gene Name

Gene ID

UniProt

Host

Reactivity

Cross Reactivity

Immunogen

Clonality

Tissue Specificity

Applications

Field of Research

Purification

Form

Function

References & Citations

Storage Conditions

Specificity

Applications Notes

Gene Name Synonym

Subcellular Location

Isotype

Contents

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