What sizes are available for Anti-DYNLT1 Antibody Picoband® Fluoro647 Conjugated?

Anti-DYNLT1 Antibody Picoband® Fluoro647 Conjugated is available in the following size(s): 100 µg/Vial.

Can this product be used for co-immunoprecipitation (Co-IP)?

Suitability for Co-IP depends on the specific antibody and is noted under validated applications on the datasheet. If it isn’t listed, contact our technical support team for guidance based on your target and sample type.

Is this kit compatible with automated liquid handling platforms?

Automation compatibility varies by kit and isn’t always listed on the datasheet. Contact our technical support team with details of your platform so we can confirm with the manufacturer.

What applications has this product been validated for?

Validated applications such as WB, ELISA, IHC, ICC, or FC are listed on the product datasheet. If you need application-specific validation data before ordering, contact our technical support team with the catalogue number.

Anti-DYNLT1 Antibody Picoband® Fluoro647 Conjugated

Q: What is the catalog number for Anti-DYNLT1 Antibody Picoband® Fluoro647 Conjugated?

The catalog number for Anti-DYNLT1 Antibody Picoband® Fluoro647 Conjugated is A05556-Fluoro647.

Q: Is Anti-DYNLT1 Antibody Picoband® Fluoro647 Conjugated in stock?

Anti-DYNLT1 Antibody Picoband® Fluoro647 Conjugated is currently made to order / not held in immediate stock. Contact us for lead time.

Product Specifications

Background

Dynein light chain Tctex-type 1 is a protein that in humans is encoded by the DYNLT1 gene. This gene encodes a component of the motor complex, cytoplasmic dynein, which transports cellular cargo along microtubules in the cell. The encoded protein regulates the length of primary cilia which are sensory organelles found on the surface of cells. The protein encoded by this gene interacts with viral proteins, like the minor capsid protein L2 of human papillomavirus, and is required for dynein-mediated delivery of the viral nucleic acid to the host nucleus. This protein interacts with oncogenic nucleoporins to disrupt gene regulation and cause leukemic transformation. Pseudogenes of this gene are present on chromosomes 4 and 17. Alternative splicing results in multiple transcript variants encoding different isoforms.

Synonyms

Dynein light chain Tctex-type 1; Protein CW-1; T-complex testis-specific protein 1 homolog; DYNLT1; TCTEL1; TCTEX-1; TCTEX1

Gene Name

DYNLT1

Gene ID

6993

UniProt

P63172

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E. coli-derived human DYNLT1 recombinant protein (Position: M1-A80) .

Clonality

Polyclonal

Tissue Specificity

Expressed in heart, placenta, skeletal muscle kidney, pancreas, spleen, prostate, testis, ovary, ileum and colon. Expressed in lung endothelial and smooth muscle cells (at protein level) .

Applications

Flow Cytometry

Field of Research

Cytoskeleton, Cytoskeleton/ECM, Dynein, Host-Virus Interaction, Interspecies Interaction, Microbiology, Motor Proteins, Signal Transduction

Purification

Immunogen affinity purified.

Form

Liquid

Function

Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Binds to transport cargos and is involved in apical cargo transport such as rhodopsin-bearing vesicles in polarized epithelia. May also be a accessory component of axonemal dynein.

References & Citations

1. Chuang, J.-Z., Yeh, T.-Y., Bollati, F., Conde, C., Canavosio, F., Caceres, A., Sung, C.-H. The dynein light chain Tctex-1 has a dynein-independent role in actin remodeling during neurite outgrowth. Dev. Cell 9: 75-86, 2005. 2. Machado, R. D., Rudarakanchana, N., Atkinson, C., Flanagan, J. A., Harrison, R., Morrell, N. W., Trembath, R. C. Functional interaction between BMPR-II and Tctex-1, a light chain of dynein, is isoform-specific and disrupted by mutations underlying primary pulmonary hypertension. Hum. Molec. Genet. 12: 3277-3286, 2003.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

13 kDa

Specificity

No cross reactivity with other proteins.

Applications Notes

Gene Name Synonym

Dynein light chain Tctex-type 1

Subcellular Location

Golgi apparatus. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Localizes to mitotic spindles.

Protein Name

Serine protease HTRA3

Isotype

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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