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Anti-Carboxypeptidase A/CPA1 Antibody Picoband® Fluoro647 Conjugated

Selected Variant

A05985-1-Fluoro647

Size: 100 µg/Vial

Product Specifications

Background

Carboxypeptidase A1 is an enzyme that in humans is encoded by the CPA1 gene. This gene encodes a member of the carboxypeptidase A family of zinc metalloproteases. This enzyme is produced in the pancreas and preferentially cleaves C-terminal branched-chain and aromatic amino acids from dietary proteins. This gene and several family members are present in a gene cluster on chromosome 7. Mutations in this gene may be linked to chronic pancreatitis, while elevated protein levels may be associated with pancreatic cancer.

Synonyms

Carboxypeptidase A1; CPA1; CPA

Gene Name

CPA1

Gene ID

1357

UniProt

P15085

Host

Rabbit

Reactivity

Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

A synthetic peptide corresponding to a sequence in the middle region of human Carboxypeptidase A, which shares 84.8% and 87% amino acid (aa) sequence identity with mouse and rat Carboxypeptidase A, respectively.

Clonality

Polyclonal

Tissue Specificity

Expressed in testis, colon, thymus and in breast cancer.

Applications

Flow Cytometry

Field of Research

Cancer, Cell Biology, Metabolic Signaling Pathways, Metabolism, Pathways and Processes, Signal Transduction

Purification

Immunogen affinity purified.

Form

Liquid

Function

Carboxypeptidase that catalyzes the release of a C- terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro.

References & Citations

1. Entrez Gene: CPA1 carboxypeptidase A1 (pancreatic) . 2. Witt, H., Beer, S., Rosendahl, J., Chen, J.-M., Candak, G. R., Masamune, A., Bence, M., Szmola, R., Oracz, G., Macek, M., Jr., Bhatia, E., Steigenberger, S., and 54 others. Variants in CPA1 are strongly associated with early onset chronic pancreatitis. Nature Genet. 45: 1216-1220, 2013.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

80420 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Carboxypeptidase A1

Subcellular Location

Secreted.

Protein Name

Long-chain-fatty-acid--CoA ligase 3

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

Price

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