Anti-Factor D/Cfd Antibody Picoband®

Factor D is a protein which in humans is encoded by the CFD gene. The protein encoded by this gene is a member of the trypsin family of peptidases. The encoded protein is a component of the alternative complement pathway best known for its role in humoral suppression of infectious agents. It is also a serine protease that is secreted by adipocytes into the bloodstream. And it stimulates glucose transport for triglyceride accumulation in fats cells and inhibits lipolysis. Finally, the encoded protein has a high level of expression in fat, suggesting a role for adipose tissue in immune system biology.

E. coli-derived rat Factor D recombinant protein (Position: I26-A263) . Mouse Factor D shares 69% and 84.5% amino acid (aa) sequence identity with human and rat Factor D, respectively.

Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway.

1. Biesma, D. H., Hannema, A. J., van Velzen-Blad, H., Mulder, L., van Zwieten, R., Kluijt, I., Roos, D. A family with complement factor D deficiency. J. Clin. Invest. 108: 233-240, 2001. 2. Ronti T, Lupattelli G, Mannarino E (April 2006) . The endocrine function of adipose tissue: an update. Clin. Endocrinol. (Oxf) 64 (4) : 355–65. 3. Volanakis JE, Narayana SV (April 1996) . Complement factor D, a novel serine protease. Protein Sci. 5 (4) : 553–64.

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.