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Anti-CD1c Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

CD1C is a group-1 member of the CD1 family of major histocompatibility (MHC) -like glycoproteins. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene is broadly distributed throughout the endocytic system via a tyrosine-based motif in the cytoplasmic tail. Alternatively spliced transcript variants of this gene have been observed, but their full-length nature is not known.

Synonyms

T-cell surface glycoprotein CD1c; CD1c; CD1C

Gene Name

CD1C

Gene ID

911

UniProt

P29017

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E. coli-derived human CD1c recombinant protein (Position: K73-L287) .

Clonality

Polyclonal

Tissue Specificity

Expressed on cortical thymocytes, on certain T-cell leukemias, and in various other tissues.

Applications

Flow Cytometry

Field of Research

Adaptive Immunity, Immunoglobulins, Immunology, Receptors, T Cells

Purification

Immunogen affinity purified.

Form

Liquid

Function

Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.

References & Citations

1. Granelli-Piperno, A., Shimeliovich, I., Pack, M., Trumpfheller, C., Steinman, R. M. HIV-1 selectively infects a subset of nonmaturing BDCA1-positive dendritic cells in human blood. J. Immun. 176: 991-998, 2006. 2. Moody, D. B., Ulrichs, T., Muhlecker, W., Young, D. C., Gurcha, S. S., Grant, E., Rosat, J.-P., Brenner, M. B., Costello, C. E., Besra, G. S., Porcelli, S. A. CD1c-mediated T-cell recognition of isoprenoid glycolipids in Mycobacterium tuberculosis infection. Nature 404: 884-888, 2000.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

CD1c molecule

Subcellular Location

Cell membrane.

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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