What sizes are available for Anti-CP110/CCP110 Antibody Picoband® Fluoro594 Conjugated?

Anti-CP110/CCP110 Antibody Picoband® Fluoro594 Conjugated is available in the following size(s): 100 µg/Vial.

What buffer is this product supplied in?

The formulation or storage buffer is listed on the product datasheet. If you require a carrier-free or custom formulation, contact us before ordering, as this may involve a made-to-order production timeline.

What dilution range is recommended for immunohistochemistry (IHC) with this antibody?

A starting IHC dilution range is listed on the datasheet, but should be optimized for your specific tissue type and staining protocol.

Can I request a Safety Data Sheet (SDS) for this product?

Yes, safety data sheets are available for hazardous or chemically classified products and can be provided on request or downloaded from the product page.

Anti-CP110/CCP110 Antibody Picoband® Fluoro594 Conjugated

Q: What is the catalog number for Anti-CP110/CCP110 Antibody Picoband® Fluoro594 Conjugated?

The catalog number for Anti-CP110/CCP110 Antibody Picoband® Fluoro594 Conjugated is A05058-1-Fluoro594.

Selected Variant

A05058-1-Fluoro594

Size: 100 µg/Vial

Product Specifications

Background

Centriolar coiled-coil protein of 110 kDa also known as centrosomal protein of 110 kDa or CP110 is a protein that in humans is encoded by the CCP110 gene. This gene is mapped to chromosome 16p12.3. It is a cell cycle-dependent CDK substrate and regulates centrosome duplication. CP110 suppresses a cilia assembly program. CCP110 functions in a protein complex that participates in the transition of centrioles from basal body function to centrosomal function.

Synonyms

Centriolar coiled-coil protein of 110 kDa; Centrosomal protein of 110 kDa; CP110; Cep110; CCP110; CEP110; CP110; KIAA0419

Gene Name

CCP110

Gene ID

9738

UniProt

O43303

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E. coli-derived human CP110 recombinant protein (Position: E51-H284) .

Clonality

Polyclonal

Tissue Specificity

Highly expressed in testis. Detected at intermediate levels in spleen, thymus, prostate, small intestine, colon and peripheral blood leukocytes.

Applications

Flow Cytometry

Field of Research

Cancer, Cell Biology, Cell Cycle, Cell Division, Cytokinesis, Organelles, Spindle, Subcellular Markers, Tags & Cell Markers

Purification

Immunogen affinity purified.

Form

Liquid

Function

Necessary for centrosome duplication at different stages of procentriole formation. Acts as a key negative regulator of ciliogenesis in collaboration with CEP97 by capping the mother centriole thereby preventing cilia formation (PubMed:17719545 PubMed:17681131, PubMed:23486064) . Also involved in promoting ciliogenesis. May play a role in the assembly of the mother centriole subdistal appendages (SDA) thereby effecting the fusion of recycling endosomes to basal bodies during cilia formation (By similarity) . Required for correct spindle formation and has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CETN2 (PubMed:16760425) .

References & Citations

1. Chen, Z., Indjeian, V. B., McManus, M., Wang, L., Dynlacht, B. D. CP110, a cell cycle-dependent CDK substrate, regulates centrosome duplication in human cells. Dev. Cell 3: 339-350, 2002. 2. Spektor A, Tsang WY, Khoo D, Dynlacht BD (August 2007) . Cep97 and CP110 suppress a cilia assembly program. Cell. 130 (4) : 678–90.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

39125 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

Gene Name Synonym

Centriolar coiled-coil protein 110

Subcellular Location

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole.

Protein Name

RNA-binding protein Musashi homolog 1

Isotype

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

Price

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