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Anti-CP110/CCP110 Antibody Picoband®

Boster Bio Anti-CP110/CCP110 Antibody Picoband® catalog # A05058-1. Tested in ELISA, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Product Specifications

Background

Centriolar coiled-coil protein of 110 kDa also known as centrosomal protein of 110 kDa or CP110 is a protein that in humans is encoded by the CCP110 gene. This gene is mapped to chromosome 16p12.3. It is a cell cycle-dependent CDK substrate and regulates centrosome duplication. CP110 suppresses a cilia assembly program. CCP110 functions in a protein complex that participates in the transition of centrioles from basal body function to centrosomal function.

Synonyms

Centriolar coiled-coil protein of 110 kDa; Centrosomal protein of 110 kDa; CP110; Cep110; CCP110; CEP110; CP110; KIAA0419

Gene Name

CCP110

Gene ID

9738

UniProt

O43303

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E. coli-derived human CP110 recombinant protein (Position: E51-H284) .

Clonality

Polyclonal

Tissue Specificity

Highly expressed in testis. Detected at intermediate levels in spleen, thymus, prostate, small intestine, colon and peripheral blood leukocytes.

Applications

ELISA, IF, IHC, ICC, WB

Field of Research

Cancer, Cell Biology, Cell Cycle, Cell Division, Cytokinesis, Organelles, Spindle, Subcellular Markers, Tags & Cell Markers

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Necessary for centrosome duplication at different stages of procentriole formation. Acts as a key negative regulator of ciliogenesis in collaboration with CEP97 by capping the mother centriole thereby preventing cilia formation (PubMed:17719545 PubMed:17681131, PubMed:23486064) . Also involved in promoting ciliogenesis. May play a role in the assembly of the mother centriole subdistal appendages (SDA) thereby effecting the fusion of recycling endosomes to basal bodies during cilia formation (By similarity) . Required for correct spindle formation and has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CETN2 (PubMed:16760425) .

References & Citations

1. Chen, Z., Indjeian, V. B., McManus, M., Wang, L., Dynlacht, B. D. CP110, a cell cycle-dependent CDK substrate, regulates centrosome duplication in human cells. Dev. Cell 3: 339-350, 2002. 2. Spektor A, Tsang WY, Khoo D, Dynlacht BD (August 2007) . Cep97 and CP110 suppress a cilia assembly program. Cell. 130 (4) : 678–90.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

39125 MW

Observed Molecular Weight

110 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Centriolar coiled-coil protein 110

Subcellular Location

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole.

Protein Name

RNA-binding protein Musashi homolog 1

Isotype

Rabbit IgG

Contents

Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

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