Anti-Complement C9 Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
Complement component 9 is a protein involved in the complement system. It participates in the formation of the Membrane Attack Complex (MAC) . The MAC assembles on bacterial membranes to form a pore, permitting disruption of bacterial membrane organization. Mutations in this gene cause component C9 deficiency. And this gene is mapped to 5p13.1.
Synonyms
Complement component C9; Complement component C9a; Complement component C9b; C9
Gene Name
C9
Gene ID
735
UniProt
P02748
Host
Rabbit
Reactivity
Human, Mouse
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E. coli-derived human Complement C9 recombinant protein (Position: K289-N515) .
Clonality
Polyclonal
Tissue Specificity
Plasma.
Applications
Flow Cytometry
Field of Research
Complement, Immunology, Innate Immunity
Purification
Immunogen affinity purified.
Form
Liquid
Function
Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C9 is the pore-forming subunit of the MAC.
References & Citations
1. Coto, E., Martinez-Naves, E., Dominguez, O., DiScipio, R. G., Urra, J. M., Lopez-Larrea, C.DNA polymorphism and linkage relationship of the human complement component C6, C7, and C9 genes. Immunogenetics 33: 184-187, 1991. 2. Hobart, M. J., Fernie, B. A., Wurzner, R., Oldroyd, R. G., Harrison, R. A., Joysey, V., Lachmann, P. J. Difficulties in the ascertainment of C9 deficiency: lessons to be drawn from a compound heterozygote C9-deficient subject. Clin. Exp. Immun. 108: 500-506, 1997.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
63173 MW
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Complement component C9
Subcellular Location
Secreted. Cell membrane; Multi-pass membrane protein. Secreted as soluble monomer. Oligomerizes at target membranes, forming a pre-pore. A conformation change then leads to the formation of a 100 Angstrom diameter pore.
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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