Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Anti-AMOTL2 Antibody Picoband®

Boster Bio Anti-AMOTL2 Antibody Picoband® catalog # A06852. Tested in ELISA, IF, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Product Specifications

Background

Angiomotin-like protein 2 is a protein that in humans is encoded by the AMOTL2 gene. Angiomotin is a protein that binds angiostatin, a circulating inhibitor of the formation of new blood vessels (angiogenesis) . It mediates angiostatin inhibition of endothelial cell migration and tube formation in vitro. The protein encoded by this gene is related to angiomotin and is a member of the motin protein family. Alternative splicing results in multiple transcript variants of this gene.

Synonyms

Angiomotin-like protein 2; Leman coiled-coil protein; LCCP; AMOTL2; KIAA0989

Gene Name

AMOTL2

Gene ID

51421

UniProt

Q9Y2J4

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E. coli-derived human AMOTL2 recombinant protein (Position: A401-Q480) .

Clonality

Polyclonal

Applications

ELISA, IF, ICC, WB

Field of Research

Cell Biology

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments. Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in angiogenesis. May play a role in the polarity, proliferation and migration of endothelial cells. Selectively promotes FGF-induced MAPK activation through SRC.

References & Citations

1. Li, Z., Wang, Y., Zhang, M., Xu, P., Huang, H., Wu, D., Meng, A. The Amotl2 gene inhibits Wnt/B-catenin signaling and regulates embryonic development in zebrafish. J. Biol. Chem. 287: 13005-13015, 2012. 2. Wang, Y., Li, Z., Xu, P., Huang, L., Tong, J., Huang, H., Meng, A. Angiomotin-like2 gene (amotl2) is required for migration and proliferation of endothelial cells during angiogenesis. J. Biol. Chem. 286: 41095-41104, 2011.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

86 kDa

Observed Molecular Weight

130-150 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Angiomotin like 2

Subcellular Location

Recycling endosome.

Isotype

Rabbit IgG

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.01mg NaN3.

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

IFNA10 Polyclonal Antibody, APC-Cy7 Conjugated
bs-7024R-APC-Cy7 100 µL

IFNA10 Polyclonal Antibody, APC-Cy7 Conjugated

Ask
View Details
KLF1 Antibody, Biotin conjugated
A55178-50UG 50 µg

KLF1 Antibody, Biotin conjugated

Ask
View Details
3-Cyano-4-methyl-2-pyridone
425235-01 100 mg

3-Cyano-4-methyl-2-pyridone

Ask
View Details
3-Cyano-4-methyl-2-pyridone
425235-02 250 mg

3-Cyano-4-methyl-2-pyridone

Ask
View Details
Human CRYAA (Alpha-crystallin A chain) ELISA Kit
EH1621 96 Tests

Human CRYAA (Alpha-crystallin A chain) ELISA Kit

Ask
View Details
Helix pomatia Lectin (HPA) - Separopore® 4B
20120062-1 2 mL

Helix pomatia Lectin (HPA) - Separopore® 4B

Ask
View Details