Anti-GRK2/GRK2 Antibody Picoband® Fluoro550 Conjugated

Product Specifications

Background

Short transient receptor potential channel 3 (TrpC3) also known as transient receptor protein 3 (TRP-3) is a protein that in humans is encoded by the TRPC3 gene. The protein encoded by this gene is a membrane protein that can form a non-selective channel permeable to calcium and other cations. The encoded protein appears to be induced to form channels by a receptor tyrosine kinase-activated phosphatidylinositol second messenger system and also by depletion of intracellular calcium stores. Two transcript variants encoding different isoforms have been found for this gene.

Synonyms

Beta-adrenergic receptor kinase 1; Beta-ARK-1; G-protein coupled receptor kinase 2

Gene Name

GRK2

Gene ID

2156

UniProt

P25098

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human GRK2, identical to the related mouse and rat sequences.

Clonality

Polyclonal

Tissue Specificity

Expressed in peripheral blood leukocytes.

Applications

Flow Cytometry

Field of Research

G Protein Signaling, Neuroscience, Neurotransmission, Receptors / Channels, Signal Transduction, Signaling Pathway

Purification

Immunogen affinity purified.

Form

Liquid

Function

Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner.

References & Citations

1. Benovic JL, DeBlasi A, Stone WC, Caron MG, Lefkowitz RJ (1989) . Beta-adrenergic receptor kinase: primary structure delineates a multigene family. Science. 246 (4927) : 235–40. 2. Pippig S, Andexinger S, Daniel K, Puzicha M, Caron MG, Lefkowitz RJ, Lohse MJ (1993) . Overexpression of beta-arrestin and beta-adrenergic receptor kinase augment desensitization of beta 2-adrenergic receptors.J. Biol. Chem. 268 (5) : 3201–8.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

96009 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

Gene Name Synonym

G protein-coupled receptor kinase 2

Subcellular Location

Cytoplasm.

Protein Name

Short transient receptor potential channel 3

Isotype

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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Anti-GRK2/GRK2 Antibody Picoband® Fluoro550 Conjugated

Product Specifications

Background

Synonyms

Gene Name

Gene ID

UniProt

Host

Reactivity

Cross Reactivity

Immunogen

Clonality

Tissue Specificity

Applications

Field of Research

Purification

Form

Function

References & Citations

Storage Conditions

Calculated Molecular Weight

Specificity

Applications Notes

Gene Name Synonym

Subcellular Location

Protein Name

Isotype

Contents

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