Anti-HE4/Wfdc2 Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
WAP four-disulfide core domain protein 2, also known as Human Epididymis Protein 4 (HE4), is a protein that in humans is encoded by the WFDC2 gene. This gene encodes a protein that is a member of the WFDC domain family. The WFDC domain, or WAP Signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. This gene is expressed in pulmonary epithelial cells, and was also found to be expressed in some ovarian cancers. The encoded protein is a small secretory protein, which may be involved in sperm maturation.
Synonyms
WAP four-disulfide core domain protein 2; Epididymal secretory protein 4; RE4; Wfdc2
Gene Name
Wfdc2
Gene ID
286888
UniProt
Q8CHN3
Host
Rabbit
Reactivity
Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E. coli-derived rat HE4 recombinant protein (Position: E31-F168) .
Clonality
Polyclonal
Tissue Specificity
Highly expressed in epithelial tissues, particularly those of the gastrointestinal and respiratory tracts, such as large intestine and trachea, followed by kidney, small intestine, appendix and stomach.
Applications
Flow Cytometry
Field of Research
Tags & Cell Markers, Tumor Associated
Purification
Immunogen affinity purified.
Form
Liquid
Function
Broad range protease inhibitor. .
References & Citations
1. Entrez Gene: WFDC2 WAP four-disulfide core domain 2. 2. Hellström I, Raycraft J, Hayden-Ledbetter M, Ledbetter JA, Schummer M, McIntosh M, Drescher C, Urban N, Hellström KE (2003-07-01) . The HE4 (WFDC2) Protein Is a Biomarker for Ovarian Carcinoma. Cancer Research63 (13) : 3695–3700. 3. Molina R, Escudero JM, Augé JM, Filella X, Foj L, Torné A, Lejarcegui J, Pahisa J (2011) . HE4 a novel tumour marker for ovarian cancer: Comparison with CA 125 and ROMA algorithm in patients with gynaecological diseases. Tumor Biology 32 (6) : 1087–95.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
33310 MW
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
WAP four-disulfide core domain 2
Subcellular Location
Secreted .
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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