Anti-TFF2 Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
Trefoil factor 2, also known as SP or SML1, is a protein that in humans is encoded by the TFF2 gene. This gene belongs to trefoil family, and members of the trefoil family may protect the mucosa from insults, stabilize the mucus layer, and affect healing of the epithelium. This gene is mapped to 21q22.3. TFF2 gene consists of 4 exons spanning 5.1 kb, with exons 2 and 3 encoding 1 trefoil domain each, and it is the only gene encoding 2 TFF-domains on separate exons. It has been found that the distribution of TFF2 and pS2 suggests involvement in repair-enhancing mechanisms.
Synonyms
Trefoil factor 2; Spasmolytic polypeptide; SP; Tff2; Sml1, Sp
Gene Name
Tff2
Gene ID
21785
UniProt
Q03404
Host
Rabbit
Reactivity
Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E. coli-derived mouse TFF2 recombinant protein (Position: E24-Y129) .
Clonality
Polyclonal
Tissue Specificity
Expressed in basement membranes of lung and kidney. Muscle- and neuron-specific isoforms are found. Isoforms (y+) with the 4 AA insert and (z+8) isoforms with the 8 AA insert are all neuron-specific. Isoforms (z+11) are found in both neuronal and non-neuronal tissues.
Applications
Flow Cytometry
Field of Research
Cell Biology
Purification
Immunogen affinity purified.
Form
Liquid
Function
Inhibits gastrointestinal motility and gastric acid secretion. Could function as a structural component of gastric mucus, possibly by stabilizing glycoproteins in the mucus gel through interactions with carbohydrate side chains (By similarity) . .
References & Citations
1. Kayademir, T., dos Santos Silva, E., Pusch, C., Beck, S., Machado, J.-C., Gott, P. A novel 25 bp tandem repeat within the human trefoil peptide gene TFF2 in 21q22.3: polymorphism and mammalian evolution. Europ. J. Hum. Genet. 6: 121-128, 1998. 2. Seib, T., Blin, N., Hilgert, K., Seifert, M., Theisinger, B., Engel, M., Dooley, S., Zang, K.-D., Welter, C. The three human trefoil genes TFF1, TFF2, and TFF3 are located within a region of 55 kb on chromosome 21q22.3. Genomics 40: 200-202, 1997.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
87148 MW
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Trefoil factor 2 (spasmolytic protein 1)
Subcellular Location
Secreted.
Protein Name
ADAM metallopeptidase domain 28
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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