What sizes are available for Anti-IL23 Receptor/Il23r Antibody Picoband® Fluoro550 Conjugated?

Anti-IL23 Receptor/Il23r Antibody Picoband® Fluoro550 Conjugated is available in the following size(s): 100 µg/Vial.

How many freeze-thaw cycles can this product tolerate?

We recommend aliquoting the product upon receipt to avoid repeated freeze-thaw cycles, which can reduce activity and stability. This is your responsibility once the product has been delivered.

Is antigen retrieval required for IHC with this antibody?

Recommended antigen retrieval methods, where applicable, are listed on the datasheet under the IHC protocol section.

What temperature does this product ship at?

Shipping temperature is chosen based on the product’s stability needs, ranging from ambient to dry ice, and is indicated on the product page. Any related shipping fee is shown clearly in your quotation.

Anti-IL23 Receptor/Il23r Antibody Picoband® Fluoro550 Conjugated

Q: What is the catalog number for Anti-IL23 Receptor/Il23r Antibody Picoband® Fluoro550 Conjugated?

The catalog number for Anti-IL23 Receptor/Il23r Antibody Picoband® Fluoro550 Conjugated is A00607-1-Fluoro550.

Selected Variant

A00607-1-Fluoro550

Size: 100 µg/Vial

Product Specifications

Background

Interleukin 23 receptor is a type I cytokine receptor. IL23R is its human gene. The protein encoded by this gene is a subunit of the receptor for IL23A/IL23. This protein pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. This protein associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner.

Synonyms

Interleukin-23 receptor; IL-23 receptor; IL-23R; Il23r

Gene Name

Il23r

Gene ID

209590

UniProt

Q8K4B4

Host

Rabbit

Reactivity

Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E. coli-derived mouse IL23 Receptor recombinant protein (Position: I25-D233) .

Clonality

Polyclonal

Tissue Specificity

Expressed by Th1, Th2 and dendritic cells.

Applications

Flow Cytometry

Field of Research

Cell Type Markers, Cytokines, Epigenetics and Nuclear Signaling, Immunoglobulins, Immunology, Innate Immunity, Interleukins, Nuclear Signaling, Nuclear Signaling Pathways, Receptors, Signal Transduction, Signaling Pathway

Purification

Immunogen affinity purified.

Form

Liquid

Function

Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis (By similarity) . .

References & Citations

1. Duerr RH, Taylor KD, Brant SR, Rioux JD, Silverberg MS, Daly MJ, et al. (Dec 2006) . A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science. 314 (5804) : 1461–3. 2. Momozawa Y, Mni M, Nakamura K, Coppieters W, Almer S, Amininejad L, et al. (Jan 2011) . Resequencing of positional candidates identifies low frequency IL23R coding variants protecting against inflammatory bowel disease. Nature Genetics. 43 (1) : 43–7.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Specificity

No cross reactivity with other proteins.

Applications Notes

Gene Name Synonym

Interleukin 23 receptor

Subcellular Location

Cell membrane ; Single-pass type I membrane protein .

Isotype

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

Price

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