Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Anti-IL17F Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

Interleukin 17F, also called IL17F is involved in the regulation of normal versus aberrant T-cell responses. This gene is mapped to 6p12.2. The protein encoded by this gene is a cytokine that shares sequence similarity with IL17. This cytokine is expressed by activated T cells, and has been shown to stimulate the production of several other cytokines, including IL6, IL8, and CSF2/GM_CSF. This cytokine is also found to inhibit the angiogenesis of endothelial cells and induce endothelial cells to produce IL2, TGFB1/TGFB, and monocyte chemoattractant protein-1. It is suggested that targeting IL17 and IL17F or antagonizing IL17R might mitigate neutrophil-mediated inflammation in CF.

Synonyms

Interleukin-17F; IL-17F; Cytokine ML-1; IL17F

Gene Name

IL17F

Gene ID

112744

UniProt

Q96PD4

Host

Rabbit

Reactivity

Human, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E. coli-derived human IL17F recombinant protein (Position: R31-Q163) .

Clonality

Polyclonal

Tissue Specificity

Expressed in activated, but not resting, CD4+ T-cells and activated monocytes.

Applications

Flow Cytometry

Field of Research

Angiogenesis, Cancer, Cardiovascular, Cytokines, Immunology, Innate Immunity, Interleukins, Invasion/Microenvironment

Purification

Immunogen affinity purified.

Form

Liquid

Function

Ligand for IL17RA and IL17RC (PubMed:17911633) . The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC (PubMed:18684971) . Involved in stimulating the production of other cytokines such as IL6, IL8 and CSF2, and in regulation of cartilage matrix turnover (PubMed:11591732, PubMed:11591768, PubMed:11574464) . Also involved in stimulating the proliferation of peripheral blood mononuclear cells and T-cells and in inhibition of angiogenesis (PubMed:11591732) . Plays a role in the induction of neutrophilia in the lungs and in the exacerbation of antigen-induced pulmonary allergic inflammation (By similarity) .

References & Citations

1. Starnes, T., Robertson, M. J., Sledge, G., Kelich, S., Nakshatri, H., Broxmeyer, H. E., Hromas, R. Cutting edge: IL-17F, a novel cytokine selectively expressed in activated T cells and monocytes, regulates angiogenesis and endothelial cell cytokine production. J. Immun. 167: 4137-4140, 2001. 2. Wang, X., Zhang, Y., Yang, X. O., Nurieva, R. I., Chang, S. H., Ojeda, S. S., Kang, H. S., Schluns, K. S., Gui, J., Jetten, A. M., Dong, C. Transcription of Il17 and Il17f is controlled by conserved noncoding sequence 2. Immunity 36: 23-31, 2012.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

37492 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Interleukin 17F

Subcellular Location

Secreted.

Protein Name

G2/mitotic-specific cyclin-B2

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

Pipettes, Graduated, Type 1, Class A
2065740/2 1 Each

Pipettes, Graduated, Type 1, Class A

Ask
View Details
FKBP51 (FKBP5) (NM_001145775) Human Tagged ORF Clone
RC227013 10 µg

FKBP51 (FKBP5) (NM_001145775) Human Tagged ORF Clone

Ask
View Details
GCHFR Antibody / GFRP
V4385-20UG 20 µg

GCHFR Antibody / GFRP

Ask
View Details
Alexa Fluor® 647 Rat IgG1, κ Isotype Ctrl
GT17107 100 µg

Alexa Fluor® 647 Rat IgG1, κ Isotype Ctrl

Ask
View Details