Anti-Vitamin D Binding protein/GC Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
Vitamin D-binding protein, also/originally known as gc-globulin (group-specific component), is a protein that in humans is encoded by the GC gene.The protein encoded by this gene belongs to the albumin gene family. It is a multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid and on the surface of many cell types. It binds to vitamin D and its plasma metabolites and transports them to target tissues.
Synonyms
Vitamin D-binding protein; DBP; VDB; Gc protein-derived macrophage activating factor
Gene Name
GC
Gene ID
2638
UniProt
P02774
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E. coli-derived human Vitamin D Binding protein recombinant protein (Position: L17-E256) .
Clonality
Polyclonal
Tissue Specificity
Expressed in the liver. Found in plasma, ascites, cerebrospinal fluid and urine.
Applications
Flow Cytometry
Field of Research
Actin Binding Proteins, Actin, etc., Cancer, Cytoskeleton, Cytoskeleton/ECM, Microfilaments, Signal Transduction, Tumor Antigens, Tumor Biomarkers, Tumor Immunology, Tumor-Associated Antigens
Purification
Immunogen affinity purified.
Form
Liquid
Function
Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation.
References & Citations
1. Mikkelsen M, Jacobsen P, Henningsen K (Jul 1977) . Possible localization of Gc-System on chromosome 4. Loss of long arm 4 material associated with father-child incompatibility within the Gc-System. Hum Hered. 27 (2) : 105–7. 2. Yamamoto N, Suyama H, Yamamoto N (2008) . Immunotherapy for Prostate Cancer with GcProtein-Derived Macrophage-Activating Factor, GcMAF ([PDF]) . TRANSLATIONAL ONCOLOGY. 1 (2) : 65–72.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
GC, vitamin D binding protein
Subcellular Location
Secreted.
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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