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Anti-Vitamin D Binding protein/GC Antibody Picoband®

Boster Bio Anti-Vitamin D Binding protein/GC Antibody Picoband® catalog # A03364-1. Tested in ELISA, IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Product Specifications

Background

Vitamin D-binding protein, also/originally known as gc-globulin (group-specific component), is a protein that in humans is encoded by the GC gene.The protein encoded by this gene belongs to the albumin gene family. It is a multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid and on the surface of many cell types. It binds to vitamin D and its plasma metabolites and transports them to target tissues.

Synonyms

Vitamin D-binding protein; DBP; VDB; Gc protein-derived macrophage activating factor

Gene Name

GC

Gene ID

2638

UniProt

P02774

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E. coli-derived human Vitamin D Binding protein recombinant protein (Position: L17-E256) .

Clonality

Polyclonal

Tissue Specificity

Expressed in the liver. Found in plasma, ascites, cerebrospinal fluid and urine.

Applications

ELISA, IHC, WB

Field of Research

Actin Binding Proteins, Actin, etc., Cancer, Cytoskeleton, Cytoskeleton/ECM, Microfilaments, Signal Transduction, Tumor Antigens, Tumor Biomarkers, Tumor Immunology, Tumor-Associated Antigens

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation.

References & Citations

1. Mikkelsen M, Jacobsen P, Henningsen K (Jul 1977) . Possible localization of Gc-System on chromosome 4. Loss of long arm 4 material associated with father-child incompatibility within the Gc-System. Hum Hered. 27 (2) : 105–7. 2. Yamamoto N, Suyama H, Yamamoto N (2008) . Immunotherapy for Prostate Cancer with GcProtein-Derived Macrophage-Activating Factor, GcMAF ([PDF]) . TRANSLATIONAL ONCOLOGY. 1 (2) : 65–72.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

53 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

GC, vitamin D binding protein

Subcellular Location

Secreted.

Isotype

Rabbit IgG

Contents

Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

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