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Anti-Follistatin/FST Antibody Picoband®

Selected Variant

A00972-1

Size: 100 µg/Vial

Boster Bio Anti-Follistatin/FST Antibody Picoband® catalog # A00972-1. Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Product Specifications

Background

Follistatin also known as activin-binding protein is a protein that in humans is encoded by the FST gene. Follistatin is an autocrine glycoprotein that is expressed in nearly all tissues of higher animals. It is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release. The single FST gene encodes two isoforms, FST317 and FST344 containing 317 and 344 amino acids respectively, resulting from alternative splicing of the precursor mRNA. In a study in which 37 candidate genes were tested for linkage and association with polycystic ovary syndrome (PCOS) or hyperandrogenemia in 150 families, evidence was found for linkage between PCOS and follistatin.

Synonyms

Follistatin; FS; Activin-binding protein; FST

Gene Name

FST

Gene ID

10468

UniProt

P19883

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E. coli-derived human Follistatin recombinant protein (Position: N31-K261) .

Clonality

Polyclonal

Tissue Specificity

Isoform 1 is the predominant isoform in serum but is undetectable in follicular fluid.

Applications

ELISA (Cap), WB

Field of Research

Atherosclerosis, Cardiovascular, Cell Biology, Cell Cycle, Cell Differentiation

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Binds ly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH) .

References & Citations

1. Tortoriello DV, Sidis Y, Holtzman DA, Holmes WE, Schneyer AL (August 2001) . Human follistatin-related protein: a structural homologue of follistatin with nuclear localization. Endocrinology. 142 (8) : 3426–34. 2. Ueno N, Ling N, Ying SY, Esch F, Shimasaki S, Guillemin R (December 1987) . Isolation and partial characterization of follistatin: a single-chain Mr 35,000 monomeric protein that inhibits the release of follicle-stimulating hormone. Proc. Natl. Acad. Sci. U.S.A. 84 (23) : 8282–6.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

40 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Follistatin

Subcellular Location

Secreted.

Isotype

Rabbit IgG

Contents

Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Price

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