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Anti-Xanthine Oxidase/XDH Antibody Picoband® Fluoro647 Conjugated

Selected Variant

A01884-Fluoro647

Size: 100 µg/Vial

Product Specifications

Background

Xanthine dehydrogenase, also known as XDH, is a protein that, in humans, is encoded by the XDH gene. Xanthine dehydrogenase belongs to the group of molybdenum-containing hydroxylases involved in the oxidative metabolism of purines. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Xanthine dehydrogenase can be converted to xanthine oxidase by reversible sulfhydryl oxidation or by irreversible proteolytic modification. Defects in xanthine dehydrogenase cause xanthinuria, may contribute to adult respiratory stress syndrome, and may potentiate influenza infection through an oxygen metabolite-dependent mechanism.

Synonyms

Xanthine dehydrogenase/oxidase; Xanthine dehydrogenase; XD;1.17.1.4 ; Xanthine oxidase; XO;1.17.3.2 ; Xanthine oxidoreductase; XOR; XDH; XDHA

Gene Name

XDH

Gene ID

7498

UniProt

P47989

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E. coli-derived human Xanthine Oxidase recombinant protein (Position: T2-K343) . Human Xanthine Oxidase shares 86.8% and 89.2% amino acid (aa) sequence identity with mouse and rat Xanthine Oxidase, respectively.

Clonality

Polyclonal

Tissue Specificity

Detected in milk (at protein level) . .

Applications

Flow Cytometry

Field of Research

Cancer, Energy Metabolism, Energy Transfer Pathways, Metabolic Signaling Pathways, Metabolism, Pathways and Processes, Signal Transduction

Purification

Immunogen affinity purified.

Form

Liquid

Function

Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species. Has also low oxidase activity towards aldehydes (in vitro) . .

References & Citations

1. Ichida K, Amaya Y, Noda K, Minoshima S, Hosoya T, Sakai O, Shimizu N, Nishino T (Nov 1993) . Cloning of the cDNA encoding human xanthine dehydrogenase (oxidase) : structural analysis of the protein and chromosomal location of the gene. Gene. 133 (2) : 279–84. 2. Parzen SD, Fox AS (Dec 1964) . Purification of xanthine dehydrogenase from drosophila melanogaster. BiochimicaetBiophysicaActa. 92: 465–71.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

146424 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Xanthine dehydrogenase/oxidase

Subcellular Location

Cytoplasm . Peroxisome . Secreted.

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

Price

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