Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Anti-TRPC6 Antibody Picoband®

Boster Bio Anti-TRPC6 Antibody Picoband® catalog # A00625. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Product Specifications

Background

Transient receptor potential cation channel, subfamily C, member 6, also known as TRPC6, is a human gene encoding a protein of the same name. The protein encoded by this gene forms a receptor-activated calcium channel in the cell membrane. The channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation of this channel occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium. Defects in this gene are a cause of focal segmental glomerulosclerosis 2 (FSGS2) .

Synonyms

Short transient receptor potential channel 6; TrpC6; Transient receptor protein 6; TRP-6; TRPC6; TRP6

Gene Name

TRPC6

Gene ID

7225

UniProt

Q9Y210

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E. coli-derived human TRPC6 recombinant protein (Position: K771-E875) . Human TRPC6 shares 82.9% amino acid (aa) sequence identity with mouse TRPC6.

Clonality

Polyclonal

Tissue Specificity

Expressed primarily in placenta, lung, spleen, ovary and small intestine. Expressed in podocytes and is a component of the glomerular slit diaphragm. .

Applications

WB

Field of Research

Calcium Channels, Calcium Signaling, Signal Transduction, Signaling Pathway

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C. Seems not to be activated by intracellular calcium store depletion.

References & Citations

1. D'Esposito, M., Strazzullo, M., Cuccurese, M., Spalluto, C., Rocchi, M., D'Urso, M., Ciccodicola, A. Identification and assignment of the human transient receptor potential channel 6 gene TRPC6 to chromosome 11q21-q22. Cytogenet. Cell Genet. 83: 46-47, 1998. 2. Hofmann, T., Obukhov, A. G., Schaefer, M., Harteneck, C., Gudermann, T., Schultz, G. activation of human TRPC6 and TRPC3 channels by diacylglycerol. Nature 397: 259-263, 1999. 3. Kwon, Y., Hofmann, T., Montell, C. Integration of phosphoinositide- and calmodulin-mediated regulation of TRPC6. Molec. Cell 25: 491-503, 2007.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

106326 MW

Observed Molecular Weight

106 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Short transient receptor potential channel 6

Subcellular Location

Membrane ; Multi-pass membrane protein .

Protein Name

Tyrosine aminotransferase

Isotype

Rabbit IgG

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

Human ZNRF4 siRNA
abx941183-01 15 nmol

Human ZNRF4 siRNA

Ask
View Details
Human ZNRF4 siRNA
abx941183-02 30 nmol

Human ZNRF4 siRNA

Ask
View Details
REA (REA-1, BAP-37, Prohibitin-related Protein, Repressor of Estrogen Receptor Activity) (Biotin) discontinued
R1280-Biotin 100 µL

REA (REA-1, BAP-37, Prohibitin-related Protein, Repressor of Estrogen Receptor Activity) (Biotin) discontinued

Ask
View Details
NDUFA5 (NM_005000) Human Recombinant Protein
PH41369M5 20 µg

NDUFA5 (NM_005000) Human Recombinant Protein

Ask
View Details
LCE2B, CT (LCE2B, LEP10, SPRL1B, XP5, Late cornified envelope protein 2B, Late envelope protein 10, Skin-specific protein Xp5, Small proline-rich-like epidermal differentiation complex protein 1B) (MaxLight 550)
MBS6315455-01 0.1 mL

LCE2B, CT (LCE2B, LEP10, SPRL1B, XP5, Late cornified envelope protein 2B, Late envelope protein 10, Skin-specific protein Xp5, Small proline-rich-like epidermal differentiation complex protein 1B) (MaxLight 550)

Ask
View Details
LCE2B, CT (LCE2B, LEP10, SPRL1B, XP5, Late cornified envelope protein 2B, Late envelope protein 10, Skin-specific protein Xp5, Small proline-rich-like epidermal differentiation complex protein 1B) (MaxLight 550)
MBS6315455-02 5x 0.1 mL

LCE2B, CT (LCE2B, LEP10, SPRL1B, XP5, Late cornified envelope protein 2B, Late envelope protein 10, Skin-specific protein Xp5, Small proline-rich-like epidermal differentiation complex protein 1B) (MaxLight 550)

Ask
View Details